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Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer
Background: Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree of hormone receptor discordance in archival paired pathological samples was evaluated. Materials and Methods: Archival data were collected on 100 patients for whom tissue f...
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| Published in: | Anticancer research 2009-05, Vol.29 (5), p.1557-1562 |
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| container_end_page | 1562 |
| container_issue | 5 |
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| container_title | Anticancer research |
| container_volume | 29 |
| creator | BROOM, Reuben J TANG, Patricia A SUMMONS, Christine BORDELEAU, Louise MULLIGAN, Anna Marie O'MALLEY, Frances P MILLER, Naomi ANDRULIS, Irene L BRENNER, Darren M LEMONS, Mark J |
| description | Background: Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree
of hormone receptor discordance in archival paired pathological samples was evaluated. Materials and Methods: Archival data
were collected on 100 patients for whom tissue from primary and metastatic sites was available. Estrogen receptor (ER), progesterone
receptor (PR) and Her-2/neu status in the primary and metastasis were compared. Results: The discordance rate for ER was 17.7%
(2-sided p=0.0039) with 9.7% of tumours changing from ER-positive to ER-negative and 8.0% changing from ER-negative to ER-positive.
The discordance rate for PR was 37.3% (2-sided p |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67241120</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67241120</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-87e433455f225249cb4cd4f2899d9d29ae3a8714e236b89d8693260720ef34a43</originalsourceid><addsrcrecordid>eNpFkMtOwzAQRSMEgvL4BeQNrIhw_IzZ0fIoEggEZR25yaQxSpxiO6r4Db4YA6WsxhqdezTXW8kokypLJad4OxlhwnEqMeZ7yb73bxgLoXK6m-xlijFKhRgln5NG2wV4ZCy69sH1C7DoGUpYht6doafvhQ_gegubNdK2QlNwKTm3MKCXoMPg0cqEBs1MBxfoyviyd5W2ZQzpEO1jCCuI5idnOu0-fgwPELSPWVOisYP4RJPvhDtMdmrdejhaz4Pk9eZ6Npmm94-3d5PL-7QhQoU0lxA7MM5rQjhhqpyzsmI1yZWqVEWUBqpzmTEgVMxzVeVCUSKwJBhqyjSjB8npr3fp-vchtiy6eDe0rbbQD74QkrAsIziCx2twmHdQFcvfEsXfL0bgZA1oX-q2drGH8RuOZIIpLPE_15hFszIOCt_pto1aWmhHVMGLjHNJvwBzMojo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67241120</pqid></control><display><type>article</type><title>Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer</title><source>EZB Free E-Journals</source><creator>BROOM, Reuben J ; TANG, Patricia A ; SUMMONS, Christine ; BORDELEAU, Louise ; MULLIGAN, Anna Marie ; O'MALLEY, Frances P ; MILLER, Naomi ; ANDRULIS, Irene L ; BRENNER, Darren M ; LEMONS, Mark J</creator><creatorcontrib>BROOM, Reuben J ; TANG, Patricia A ; SUMMONS, Christine ; BORDELEAU, Louise ; MULLIGAN, Anna Marie ; O'MALLEY, Frances P ; MILLER, Naomi ; ANDRULIS, Irene L ; BRENNER, Darren M ; LEMONS, Mark J</creatorcontrib><description>Background: Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree
of hormone receptor discordance in archival paired pathological samples was evaluated. Materials and Methods: Archival data
were collected on 100 patients for whom tissue from primary and metastatic sites was available. Estrogen receptor (ER), progesterone
receptor (PR) and Her-2/neu status in the primary and metastasis were compared. Results: The discordance rate for ER was 17.7%
(2-sided p=0.0039) with 9.7% of tumours changing from ER-positive to ER-negative and 8.0% changing from ER-negative to ER-positive.
The discordance rate for PR was 37.3% (2-sided p<0.0001), with all of these tumours changing from PR-positive to PR-negative.
No significant discordance for Her-2/neu was found. Conclusions: This series suggests that significant discordance exists
for hormone receptor status between primary and metastatic breast cancer samples. Loss of PR was particularly frequent.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 19443366</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Neoplasm Metastasis ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Tumors</subject><ispartof>Anticancer research, 2009-05, Vol.29 (5), p.1557-1562</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21649070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19443366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BROOM, Reuben J</creatorcontrib><creatorcontrib>TANG, Patricia A</creatorcontrib><creatorcontrib>SUMMONS, Christine</creatorcontrib><creatorcontrib>BORDELEAU, Louise</creatorcontrib><creatorcontrib>MULLIGAN, Anna Marie</creatorcontrib><creatorcontrib>O'MALLEY, Frances P</creatorcontrib><creatorcontrib>MILLER, Naomi</creatorcontrib><creatorcontrib>ANDRULIS, Irene L</creatorcontrib><creatorcontrib>BRENNER, Darren M</creatorcontrib><creatorcontrib>LEMONS, Mark J</creatorcontrib><title>Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree
of hormone receptor discordance in archival paired pathological samples was evaluated. Materials and Methods: Archival data
were collected on 100 patients for whom tissue from primary and metastatic sites was available. Estrogen receptor (ER), progesterone
receptor (PR) and Her-2/neu status in the primary and metastasis were compared. Results: The discordance rate for ER was 17.7%
(2-sided p=0.0039) with 9.7% of tumours changing from ER-positive to ER-negative and 8.0% changing from ER-negative to ER-positive.
The discordance rate for PR was 37.3% (2-sided p<0.0001), with all of these tumours changing from PR-positive to PR-negative.
No significant discordance for Her-2/neu was found. Conclusions: This series suggests that significant discordance exists
for hormone receptor status between primary and metastatic breast cancer samples. Loss of PR was particularly frequent.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpFkMtOwzAQRSMEgvL4BeQNrIhw_IzZ0fIoEggEZR25yaQxSpxiO6r4Db4YA6WsxhqdezTXW8kokypLJad4OxlhwnEqMeZ7yb73bxgLoXK6m-xlijFKhRgln5NG2wV4ZCy69sH1C7DoGUpYht6doafvhQ_gegubNdK2QlNwKTm3MKCXoMPg0cqEBs1MBxfoyviyd5W2ZQzpEO1jCCuI5idnOu0-fgwPELSPWVOisYP4RJPvhDtMdmrdejhaz4Pk9eZ6Npmm94-3d5PL-7QhQoU0lxA7MM5rQjhhqpyzsmI1yZWqVEWUBqpzmTEgVMxzVeVCUSKwJBhqyjSjB8npr3fp-vchtiy6eDe0rbbQD74QkrAsIziCx2twmHdQFcvfEsXfL0bgZA1oX-q2drGH8RuOZIIpLPE_15hFszIOCt_pto1aWmhHVMGLjHNJvwBzMojo</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>BROOM, Reuben J</creator><creator>TANG, Patricia A</creator><creator>SUMMONS, Christine</creator><creator>BORDELEAU, Louise</creator><creator>MULLIGAN, Anna Marie</creator><creator>O'MALLEY, Frances P</creator><creator>MILLER, Naomi</creator><creator>ANDRULIS, Irene L</creator><creator>BRENNER, Darren M</creator><creator>LEMONS, Mark J</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer</title><author>BROOM, Reuben J ; TANG, Patricia A ; SUMMONS, Christine ; BORDELEAU, Louise ; MULLIGAN, Anna Marie ; O'MALLEY, Frances P ; MILLER, Naomi ; ANDRULIS, Irene L ; BRENNER, Darren M ; LEMONS, Mark J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-87e433455f225249cb4cd4f2899d9d29ae3a8714e236b89d8693260720ef34a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BROOM, Reuben J</creatorcontrib><creatorcontrib>TANG, Patricia A</creatorcontrib><creatorcontrib>SUMMONS, Christine</creatorcontrib><creatorcontrib>BORDELEAU, Louise</creatorcontrib><creatorcontrib>MULLIGAN, Anna Marie</creatorcontrib><creatorcontrib>O'MALLEY, Frances P</creatorcontrib><creatorcontrib>MILLER, Naomi</creatorcontrib><creatorcontrib>ANDRULIS, Irene L</creatorcontrib><creatorcontrib>BRENNER, Darren M</creatorcontrib><creatorcontrib>LEMONS, Mark J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BROOM, Reuben J</au><au>TANG, Patricia A</au><au>SUMMONS, Christine</au><au>BORDELEAU, Louise</au><au>MULLIGAN, Anna Marie</au><au>O'MALLEY, Frances P</au><au>MILLER, Naomi</au><au>ANDRULIS, Irene L</au><au>BRENNER, Darren M</au><au>LEMONS, Mark J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>29</volume><issue>5</issue><spage>1557</spage><epage>1562</epage><pages>1557-1562</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree
of hormone receptor discordance in archival paired pathological samples was evaluated. Materials and Methods: Archival data
were collected on 100 patients for whom tissue from primary and metastatic sites was available. Estrogen receptor (ER), progesterone
receptor (PR) and Her-2/neu status in the primary and metastasis were compared. Results: The discordance rate for ER was 17.7%
(2-sided p=0.0039) with 9.7% of tumours changing from ER-positive to ER-negative and 8.0% changing from ER-negative to ER-positive.
The discordance rate for PR was 37.3% (2-sided p<0.0001), with all of these tumours changing from PR-positive to PR-negative.
No significant discordance for Her-2/neu was found. Conclusions: This series suggests that significant discordance exists
for hormone receptor status between primary and metastatic breast cancer samples. Loss of PR was particularly frequent.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>19443366</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Neoplasm Metastasis Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Tumors |
| title | Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer |
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