The significance of apolipoprotein-B (Apo-B) in the elderly as a predictive factor of cardio-cerebrovascular complications

Abstract In an elderly pool of 3288 subjects (65–84 years of age), taking part in the Italian Longitudinal Studies on Aging (ILSA). We evaluated the prevalence of acute myocardial infarction (AMI), the stroke, the non-fatal AMI + stroke cases in relation to the larger or smaller values of the apolip...

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Bibliographic Details
Published in:Archives of gerontology and geriatrics 2009-07, Vol.49 (1), p.162-164
Main Authors: Motta, Massimo, Bennati, Ettore, Cardillo, Elisabeth, Ferlito, Laura, Passamonte, Michela, Malaguarnera, Mariano
Format: Article
Language:English
Subjects:
Acute myocardial infarction (AMI)
Aged
Aged, 80 and over
Apolipoprotein
Apolipoprotein-B
Apolipoproteins B - genetics
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - genetics
Coronary Artery Disease - epidemiology
Coronary Artery Disease - genetics
Dyslipidemias - epidemiology
Dyslipidemias - genetics
Elderly people
Female
Genotype
Humans
Internal Medicine
Male
Metabolic syndrome
Metabolic syndrome in elderly
Myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - genetics
Pathology
Predictive Value of Tests
Prospective Studies
Stroke - epidemiology
Stroke - genetics
Stroke in elderly
Strokes
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Summary:Abstract In an elderly pool of 3288 subjects (65–84 years of age), taking part in the Italian Longitudinal Studies on Aging (ILSA). We evaluated the prevalence of acute myocardial infarction (AMI), the stroke, the non-fatal AMI + stroke cases in relation to the larger or smaller values of the apolipoprotein-B (Apo-B) level considered as cutoff point of normality (150 mg/100 ml). In addition, during the follow-up of 3 years, we observed the prevalence of all these pathologies (AMI, stroke, non-fatal AMI + stroke) in the subjects who had none of these syndromes at the start of the study period. At last, we studied the percentual occurrence of the parameters indicated by the IDF as signs of the metabolic syndrome (MS), and compared them between the subjects displaying higher or lower values of Apo-B of the normal level. Our results revealed that the Apo-B value may be considered as a predictive factor of lipidemic, atherogenic alterations, and it merits in this sense to be included in the diagnostic criteria of MS. However, it cannot be considered as an independent factor of preventive diagnosis of the non-fatal cardio-cerebrovascular complications.
ISSN:0167-4943
1872-6976
DOI:10.1016/j.archger.2008.07.001