Platinum(II)-Catalyzed Intramolecular Cyclization of o-Substituted Aryl Alkynes through sp³ C----H Activation

Ring leader: PtCl₂ catalyzes intramolecular cyclization of o-isopropyl or o-benzyl aryl alkynes to give substituted indene derivatives with good yields and high selectivity. This reaction appears to proceed through an sp³ C---H activation and 1,4-hydrogen migration pathway (see scheme).

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (22), p.3999-4001
Main Authors: Yang, Shangdong, Li, Zigang, Jian, Xing, He, Chuan
Format: Article
Language:English
Subjects:
alkynes
Alkynes - chemistry
Carbon - chemistry
Catalysis
Cyclization
CH activation
Hydrogen - chemistry
indenes
Indenes - chemical synthesis
platinum
Platinum - chemistry
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Description
Summary:Ring leader: PtCl₂ catalyzes intramolecular cyclization of o-isopropyl or o-benzyl aryl alkynes to give substituted indene derivatives with good yields and high selectivity. This reaction appears to proceed through an sp³ C---H activation and 1,4-hydrogen migration pathway (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200900368