Nonlymphoid peritoneal cells suppress the T cell response to Mls

Comparative analyses of the ability of lymphoid tissue to present the minor lymphocyte stimulatory (Mls) superantigen Mls-1 a in vitro revealed that all tissues containing mature B cells, except peritoneal cavity (PerC) cells, induced Mls-1 a-specific T cell activation. Irradiation and mitomycin C t...

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Bibliographic Details
Published in:Immunobiology (1979) 2004-01, Vol.209 (8), p.575-584
Main Authors: Rosini, Laura, Matlack, Robin, Taylor, Justin, Howell, Koko F., Yeh, Kenneth, Pennello, Anthony, Riggs, James E.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antigen-Presenting Cells - drug effects
Antigen-Presenting Cells - immunology
Antigen-Presenting Cells - radiation effects
Apoptosis
B-Lymphocytes - immunology
Cell Communication - immunology
Coculture Techniques
Cytokines - immunology
Cytokines - pharmacology
Cytokines - physiology
Female
Immune Tolerance
Lymphocyte Activation - immunology
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
Male
Mice
Mice, Inbred Strains
Mice, Mutant Strains
Minor Lymphocyte Stimulatory Antigens - immunology
Mitomycin - pharmacology
Mls
Peritoneal Cavity - cytology
Superantigens
Suppression
T-Lymphocytes - immunology
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Summary:Comparative analyses of the ability of lymphoid tissue to present the minor lymphocyte stimulatory (Mls) superantigen Mls-1 a in vitro revealed that all tissues containing mature B cells, except peritoneal cavity (PerC) cells, induced Mls-1 a-specific T cell activation. Irradiation and mitomycin C treatment, addition of IL-2 and IL-12, and neutralization of IL-10 and TGF-β did not restore Mls-1 a antigen presentation by PerC cells. Co-culture studies revealed that PerC cells actively suppress the T cell response to Mls-1 a. PerC cells from severe-combined immune-defective (SCID) mice also suppressed this response indicating that nonlymphoid cells mediate this effect. These results suggest that in addition to antigen processing and presentation, resident peritoneal cavity cells may temper lymphocyte activation.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2004.07.002