Middle ear adenoma with neuroendocrine differentiation (MEA-ND) in the pediatric population

Abstract Middle ear adenoma with neuroendocrine differentiation is an uncommon tumor of the tympanic cavity. The terminology of this entity has suffered due to a poor understanding of the differentiation of these neoplasms, and has included both “adenoma” as well as “carcinoid tumor.” Immunohistoche...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2009-06, Vol.73 (6), p.895-898
Main Authors: Dogru, Salim, Wilkinson, Eric P, Robinson, Robert A, Smith, Richard J.H
Format: Article
Language:English
Subjects:
Adenoma
Adenoma - pathology
Adenoma - surgery
Adolescent
Biopsy
Carcinoid tumor
Diagnosis, Differential
Ear Neoplasms - pathology
Ear Neoplasms - surgery
Ear, Middle - pathology
Ear, Middle - surgery
Humans
Male
Middle ear
Neuroendocrine Cells - pathology
Neuroendocrine tumor
Otolaryngology
Pediatrics
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Summary:Abstract Middle ear adenoma with neuroendocrine differentiation is an uncommon tumor of the tympanic cavity. The terminology of this entity has suffered due to a poor understanding of the differentiation of these neoplasms, and has included both “adenoma” as well as “carcinoid tumor.” Immunohistochemical techniques have helped clarify that these tumors all share elements of neuroendocrine differentiation. Occurrences of this tumor in the pediatric population are extremely rare. In the world literature, only three pediatric cases of middle ear adenoma with neuroendocrine differentiation have been described. We report the youngest case to date of middle ear adenoma with neuroendocrine differentiation, in a 13-year-old boy. We discuss the differential diagnosis, surgical management, and pathology of this entity.
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2009.02.014