Assessment of Left Ventricular Volumes and Function: Intraindividual Comparison of Multi-slice Spiral CT and Electron Beam CT in an Animal Model

• Published in: Acta radiologica (1987) 2004-12, Vol.45 (8), p.819-827
• Main Authors: Wiese, T. H., Rogalla, P., Taupitz, M., Wagner, S., Schnorr, J., Mews, J., Enzweiler, C. N. H., Hermann, K.-G. A., Hamm, B., Lembcke, A.
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Heart Ventricles - anatomy & histology; Heart Ventricles - diagnostic imaging; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Models, Animal; Stroke Volume; Swine; Swine, Miniature; Tomography, Spiral Computed; Tomography, X-Ray Computed; Ventricular Function, Left
• ISSN: 0284-1851; 1600-0455
• DOI: 10.1080/02841850410008720

Purpose: To evaluate multi-slice spiral computed tomography (MSCT) for measurements of left ventricular volumes, ejection fraction (EF), and myocardial mass in comparison with electron beam CT (EBCT) as a reference method. Material and Methods: Six minipigs underwent both standardized contrast-enhanced MSCT (effective acquisition time per cardiac cycle 125.7±30.1 ms, reconstructed slice thickness 8 mm) and EBCT (acquisition time 50 ms, collimated slice thickness 8 mm). The contrast-to-noise ratio of the left ventricle was measured in each animal, and the contour sharpness of the myocardium was analyzed. Volumes (EDV, ESV, SV) ejection fraction (EF), and muscle mass were calculated by MSCT and by EBCT using the slice summation method. Results: MSCT had a higher contrast-to-noise ratio and delineated the myocardial contours more sharply than EBCT. There was a close linear correlation between both modalities for all parameters (EDV: rP=0.88, ESV: rP=0.91, SV: rP=0.85, EF: rP=0.93; mass: rP=0.90; P