Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007

Abstract We isolated and identified six subgenogroups (B2, B4, B5, C1, C2, and C4) of enterovirus 71 (EV71) between 1990 and 2007 in Yamagata, Japan. We measured neutralizing antibody (NT Ab) titers against those subgenogroup strains and the BrCr reference strain for antigenic analysis. Serological...

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Bibliographic Details
Published in:Vaccine 2009-05, Vol.27 (24), p.3153-3158
Main Authors: Mizuta, K, Aoki, Y, Suto, A, Ootani, K, Katsushima, N, Itagaki, T, Ohmi, A, Okamoto, M, Nishimura, H, Matsuzaki, Y, Hongo, S, Sugawara, K, Shimizu, H, Ahiko, T
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Viral - blood
Applied microbiology
Biological and medical sciences
Cross-antigenicity
Encephalitis
Enterovirus
Enterovirus A, Human - classification
Enterovirus A, Human - genetics
Enterovirus A, Human - immunology
Enterovirus A, Human - isolation & purification
Enterovirus type 71
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genotype
Genotypes
Guinea Pigs
Immunization
Infections
Infectious diseases
Japan
Laboratory animals
Microbiology
Miscellaneous
Neutralization
Neutralization Tests
Phylogeny
Studies
Subgenogroup
Surveillance
Time Factors
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virology
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Summary:Abstract We isolated and identified six subgenogroups (B2, B4, B5, C1, C2, and C4) of enterovirus 71 (EV71) between 1990 and 2007 in Yamagata, Japan. We measured neutralizing antibody (NT Ab) titers against those subgenogroup strains and the BrCr reference strain for antigenic analysis. Serological analysis of 83 residents in Yamagata in 2004 showed that differences in the NT Ab titer of each individual against the different subgenogroups were mostly within 4-fold. Furthermore, sera from guinea pigs, immunized with the B2 and C1 strains indicated cross-antigenicity among the seven different subgenogroups. In conclusion, our results showed that cross-antigenicity exists among EV71 strains from different subgenogroups circulating in the community through genomic evolution. Our results also suggest that eliciting neutralizing antibodies against one genotype is likely to confer cross-neutralization against other genotypes.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.03.060