Unusual Photoinduced Response of mTHPC Liposomal Formulation (Foslip)

Liposomal formulations of meso‐tetra(hydroxyphenyl)chlorin (mTHPC) have already been proposed with the aim to optimize photodynamic therapy. Spectral modifications of these compounds upon irradiation have not yet been investigated. The objective of this study was to evaluate photobleaching propertie...

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Bibliographic Details
Published in:Photochemistry and photobiology 2009-05, Vol.85 (3), p.719-724
Main Authors: Kachatkou, Dzmitry, Sasnouski, Siarhei, Zorin, Vladimir, Zorina, Tatyana, D'Hallewin, Marie-Ange, Guillemin, Francois, Bezdetnaya, Lina
Format: Article
Language:English
Subjects:
Fluorescence
Light
Liposomes
Mesoporphyrins - chemistry
Photochemistry
Photodynamic therapy
Proteins
Quenching
Studies
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Summary:Liposomal formulations of meso‐tetra(hydroxyphenyl)chlorin (mTHPC) have already been proposed with the aim to optimize photodynamic therapy. Spectral modifications of these compounds upon irradiation have not yet been investigated. The objective of this study was to evaluate photobleaching properties of mTHPC encapsulated into dipalmitoylphosphatidylcholine (DPPC) liposomes, Foslip. Fluorescence measurements in DPPC liposomes with different DPPC:mTHPC ratios demonstrated a dramatic decrease in fluorescence anisotropy with increasing local mTHPC concentration, thus suggesting strong interactions between mTHPC molecules in lipid bulk medium. Exposure of Foslip suspensions to small light doses (
ISSN:0031-8655
1751-1097
DOI:10.1111/j.1751-1097.2008.00466.x