Vascular endothelial growth factor A and C gene expression in endometriosis

• Published in: Human pathology 2004-11, Vol.35 (11), p.1369-1375
• Main Authors: Takehara, Mikio, Ueda, Masatsugu, Yamashita, Yoshiki, Terai, Yoshito, Hung, Yao-Ching, Ueki, Minoru
• Format: Article
• Language: English
• Subjects: angiogenesis; Biological and medical sciences; DNA Primers - chemistry; Endometriosis; Endometriosis - genetics; Endometriosis - metabolism; Endometriosis - pathology; Endometrium - blood supply; Endometrium - metabolism; Endometrium - pathology; Female; Female genital diseases; Gene Expression; Gynecology. Andrology. Obstetrics; Humans; Immunoenzyme Techniques; Investigative techniques, diagnostic techniques (general aspects); lymphangiogenesis; Medical sciences; Menstrual Cycle - metabolism; Neovascularization, Pathologic; Non tumoral diseases; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Peritoneum - metabolism; Peritoneum - pathology; Proteins; Reproductive health; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Vascular endothelial growth factor; vascular endothelial growth factor A; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; vascular endothelial growth factor C; Vascular Endothelial Growth Factor C - genetics; Vascular Endothelial Growth Factor C - metabolism
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/j.humpath.2004.07.020

Angiogenesis is essential for the pathogenesis of endometriosis. Gene expression levels of vascular endothelial growth factor (VEGF) A and C in 10 eutopic endometrial, 23 normal peritoneal, and 62 endometriotic tissues surgically obtained from 47 women with endometriosis (group 2) were compared with those in 12 control eutopic endometrial and 9 normal peritoneal tissues from 15 women without endometriosis (group 1). VEGF-A mRNA expression levels in eutopic endometrium of group 2 were higher than those of group 1 throughout the menstrual cycle ( P