Tumour enhancing fraction (EnF) in glioma: relationship to tumour grade

The aim of this research was to determine whether the proportion of a tumour that enhances (enhancing fraction, EnF) and changes in EnF with enhancement threshold differ between low and high grade glioma. Forty-four patients (45 gliomas comprising 16 grade II, 5 grade III and 24 grade IV) were studi...

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Bibliographic Details
Published in:European radiology 2009-06, Vol.19 (6), p.1489-1498
Main Authors: Mills, Samantha J., Soh, Calvin, O’Connor, James P. B., Rose, Chris J., Buonaccorsi, Giovanni A., Cheung, Susan, Zhao, Sha, Parker, Geoff J. M., Jackson, Alan
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Brain cancer
Chemotherapy
Contrast agents
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Female
Glioblastoma - diagnosis
Glioma - diagnosis
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging
Internal Medicine
Interventional Radiology
Intracranial pressure
Male
Medicine
Medicine & Public Health
Middle Aged
Neuro
Neuroradiology
Radiology
Reproducibility of Results
Sensitivity and Specificity
Tumors
Ultrasound
Young Adult
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Summary:The aim of this research was to determine whether the proportion of a tumour that enhances (enhancing fraction, EnF) and changes in EnF with enhancement threshold differ between low and high grade glioma. Forty-four patients (45 gliomas comprising 16 grade II, 5 grade III and 24 grade IV) were studied. Imaging included pre- and post-contrast-enhanced T 1 -weighted sequences and T 1 -weighted DCE-MRI. Thresholded enhancement maps were generated for each tumour by using a range of values of the initial area under the contrast concentration curve (IAUC). A plot of EnF versus threshold value was generated. We examined the relationship between tumour grade and enhancement metrics including: EnF (threshold IAUC > 0 mMol s), EnF (threshold IAUC > 2.5 mMol s), initial slope of the EnF/threshold curve (∂EnF), IAUC, and two previously described signal-intensity-based metrics. EnF, defined as the proportion of tumour showing any enhancement (threshold IAUC > 0 mMol s), showed no difference between low and high grade glioma. All other measures demonstrated significant differences between grade II and IV, and low (grade II) and high grade (grades III/ IV) gliomas ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-008-1288-z