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Increased concentrations of lipoprotein(a), circadian rhythms and metabolic reactions evoked by acute myocardial infarction, associated with acute reactions in relation to large breakfasts
Of 54 patients with acute coronary artery disease (CAD) that were included in this study, 41 patients had acute myocardial infarction (AMI), five patients possible MI, four patients unstable angina and the remaining four angina pectoris. The control subjects ( n=85) were randomly selected from the g...
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| Published in: | Biomedicine & pharmacotherapy 2004-10, Vol.58, p.S116-S122 |
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| container_title | Biomedicine & pharmacotherapy |
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| creator | Singh, Ram B. Pella, Daniel Sharma, Jagdish P. Rastogi, Saurabh Kartikey, Kumar Goel, Vijay K. Sharma, Rakesh Neki, Narankar S. Kumar, Adarsh Otsuka, Kuniaki |
| description | Of 54 patients with acute coronary artery disease (CAD) that were included in this study, 41 patients had acute myocardial infarction (AMI), five patients possible MI, four patients unstable angina and the remaining four angina pectoris. The control subjects (
n=85) were randomly selected from the general population of the city of Moradabad of similar age range after exclusion for CAD (
n=9), diabetes (
n=6) and excess intake of trans fatty acids (
n=20). The incidence of lipoprotein(a) excess (>30 mg/dl; 42.6 vs 24.7%;
P |
| doi_str_mv | 10.1016/S0753-3322(04)80019-2 |
| format | article |
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n=85) were randomly selected from the general population of the city of Moradabad of similar age range after exclusion for CAD (
n=9), diabetes (
n=6) and excess intake of trans fatty acids (
n=20). The incidence of lipoprotein(a) excess (>30 mg/dl; 42.6 vs 24.7%;
P<0.05) and mean concentration of lipoprotein(a) (Lp[a], 6.4 mg/dl, 95% confidence interval: 2.8–10.5;
P<0.05) was significantly greater in the acute CAD group compared with control subjects. Mean total cholesterol and triglycerides were significantly higher and mean nitrite level lower in the study group as compared with the control group. There was a significant greater incidence of cardiac events in the second quarter of the day compared with the fourth quarter. Lp(a), triglycerides, blood glucose, plasma insulin, malondialdehyde, diene conjugates, TBARS and TNF-alpha and IL-6 levels, which were significantly greater during the acute phase, showed a significant decline and serum nitrite and coenzyme Q demonstrated an increase at 4 weeks of follow-up when the acute reactions evoked by MI had been controlled. Large breakfasts were a predisposing factor for cardiac events in the second quarter of the day and it was significantly associated with metabolic reactions. The findings indicate that acute reactions as a result or as circadian rhythms appear to be important in the pathogenesis of AMI-associated complications and that a large breakfast in association with nitrite deficiency may further trigger the circadian rhythms. However, more studies in a larger number of subjects would be necessary in order to confirm our findings.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/S0753-3322(04)80019-2</identifier><identifier>PMID: 15754849</identifier><identifier>CODEN: BIPHEX</identifier><language>eng</language><publisher>Paris: Elsevier SAS</publisher><subject>Acute Disease ; Biological and medical sciences ; Biotransformation ; Blood Glucose ; Cardiac event ; Cholesterol - blood ; Circadian rhythm ; Circadian Rhythm - physiology ; Coenzyme Q ; Coronary Artery Disease - blood ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnosis ; Cytokines ; Diet - adverse effects ; Diet - methods ; Glucose ; Humans ; India - ethnology ; Insulin ; Large breakfast ; Lipoprotein(a) ; Lipoproteins - blood ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - metabolism ; Myocardial Infarction - physiopathology ; Nitric oxide ; Nitrite ; Pharmacology. Drug treatments ; Total cholesterol ; Triglycerides - blood</subject><ispartof>Biomedicine & pharmacotherapy, 2004-10, Vol.58, p.S116-S122</ispartof><rights>2004 Elsevier SAS. All rights reserved</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-d7bf57e3902219dd8d604f6002b7580eb4c0d3c50558c0c7322c29e425147d9d3</citedby><cites>FETCH-LOGICAL-c393t-d7bf57e3902219dd8d604f6002b7580eb4c0d3c50558c0c7322c29e425147d9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16217674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15754849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Ram B.</creatorcontrib><creatorcontrib>Pella, Daniel</creatorcontrib><creatorcontrib>Sharma, Jagdish P.</creatorcontrib><creatorcontrib>Rastogi, Saurabh</creatorcontrib><creatorcontrib>Kartikey, Kumar</creatorcontrib><creatorcontrib>Goel, Vijay K.</creatorcontrib><creatorcontrib>Sharma, Rakesh</creatorcontrib><creatorcontrib>Neki, Narankar S.</creatorcontrib><creatorcontrib>Kumar, Adarsh</creatorcontrib><creatorcontrib>Otsuka, Kuniaki</creatorcontrib><title>Increased concentrations of lipoprotein(a), circadian rhythms and metabolic reactions evoked by acute myocardial infarction, associated with acute reactions in relation to large breakfasts</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Of 54 patients with acute coronary artery disease (CAD) that were included in this study, 41 patients had acute myocardial infarction (AMI), five patients possible MI, four patients unstable angina and the remaining four angina pectoris. The control subjects (
n=85) were randomly selected from the general population of the city of Moradabad of similar age range after exclusion for CAD (
n=9), diabetes (
n=6) and excess intake of trans fatty acids (
n=20). The incidence of lipoprotein(a) excess (>30 mg/dl; 42.6 vs 24.7%;
P<0.05) and mean concentration of lipoprotein(a) (Lp[a], 6.4 mg/dl, 95% confidence interval: 2.8–10.5;
P<0.05) was significantly greater in the acute CAD group compared with control subjects. Mean total cholesterol and triglycerides were significantly higher and mean nitrite level lower in the study group as compared with the control group. There was a significant greater incidence of cardiac events in the second quarter of the day compared with the fourth quarter. Lp(a), triglycerides, blood glucose, plasma insulin, malondialdehyde, diene conjugates, TBARS and TNF-alpha and IL-6 levels, which were significantly greater during the acute phase, showed a significant decline and serum nitrite and coenzyme Q demonstrated an increase at 4 weeks of follow-up when the acute reactions evoked by MI had been controlled. Large breakfasts were a predisposing factor for cardiac events in the second quarter of the day and it was significantly associated with metabolic reactions. The findings indicate that acute reactions as a result or as circadian rhythms appear to be important in the pathogenesis of AMI-associated complications and that a large breakfast in association with nitrite deficiency may further trigger the circadian rhythms. However, more studies in a larger number of subjects would be necessary in order to confirm our findings.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Blood Glucose</subject><subject>Cardiac event</subject><subject>Cholesterol - blood</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Coenzyme Q</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Cytokines</subject><subject>Diet - adverse effects</subject><subject>Diet - methods</subject><subject>Glucose</subject><subject>Humans</subject><subject>India - ethnology</subject><subject>Insulin</subject><subject>Large breakfast</subject><subject>Lipoprotein(a)</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - metabolism</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Nitric oxide</subject><subject>Nitrite</subject><subject>Pharmacology. Drug treatments</subject><subject>Total cholesterol</subject><subject>Triglycerides - blood</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkUFv1DAQhS0EokvhJ4B8AbVSA7YTx8mpQlULlSpxAM6WM56wpom92N6i_W_8ONzdiD1ymsN8783oPUJec_aeM95--MqUrKu6FuKMNecdY7yvxBOy4r1kVcuYekpW_5AT8iKln4wx2dbdc3LCpZJN1_Qr8ufWQ0ST0FIIHtDnaLILPtEw0sltwiaGjM6fmfMLCi6Csc54Gte7vJ4TNd7SGbMZwuSAFiM4iPEh3BfLYUcNbDPSeRfAxCKdqPOjiXvsgpqUAjiTC_rb5fUCH21cuYTT_iGaA51M_IF0KPv70aScXpJno5kSvlrmKfl-c_3t6nN19-XT7dXHuwrqvs6VVcMoFdY9E4L31na2Zc1YMhKDkh3DoQFma5BMyg4YqBIYiB4bIXmjbG_rU_Lu4FvC-LXFlPXsEuA0GY9hm3SrhOy6XhZQHkCIIaWIo95EN5u405zpx9r0vjb92Ilmjd7XpkXRvVkObIcZ7VG19FSAtwtgEphpjMaDS0euFVy1qinc5YHDEseDw6gTOCy9WhcRsrbB_eeVvyLzuKY</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Singh, Ram B.</creator><creator>Pella, Daniel</creator><creator>Sharma, Jagdish P.</creator><creator>Rastogi, Saurabh</creator><creator>Kartikey, Kumar</creator><creator>Goel, Vijay K.</creator><creator>Sharma, Rakesh</creator><creator>Neki, Narankar S.</creator><creator>Kumar, Adarsh</creator><creator>Otsuka, Kuniaki</creator><general>Elsevier SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Increased concentrations of lipoprotein(a), circadian rhythms and metabolic reactions evoked by acute myocardial infarction, associated with acute reactions in relation to large breakfasts</title><author>Singh, Ram B. ; Pella, Daniel ; Sharma, Jagdish P. ; Rastogi, Saurabh ; Kartikey, Kumar ; Goel, Vijay K. ; Sharma, Rakesh ; Neki, Narankar S. ; Kumar, Adarsh ; Otsuka, Kuniaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-d7bf57e3902219dd8d604f6002b7580eb4c0d3c50558c0c7322c29e425147d9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Biotransformation</topic><topic>Blood Glucose</topic><topic>Cardiac event</topic><topic>Cholesterol - blood</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Coenzyme Q</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Cytokines</topic><topic>Diet - adverse effects</topic><topic>Diet - methods</topic><topic>Glucose</topic><topic>Humans</topic><topic>India - ethnology</topic><topic>Insulin</topic><topic>Large breakfast</topic><topic>Lipoprotein(a)</topic><topic>Lipoproteins - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - metabolism</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Nitric oxide</topic><topic>Nitrite</topic><topic>Pharmacology. Drug treatments</topic><topic>Total cholesterol</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Ram B.</creatorcontrib><creatorcontrib>Pella, Daniel</creatorcontrib><creatorcontrib>Sharma, Jagdish P.</creatorcontrib><creatorcontrib>Rastogi, Saurabh</creatorcontrib><creatorcontrib>Kartikey, Kumar</creatorcontrib><creatorcontrib>Goel, Vijay K.</creatorcontrib><creatorcontrib>Sharma, Rakesh</creatorcontrib><creatorcontrib>Neki, Narankar S.</creatorcontrib><creatorcontrib>Kumar, Adarsh</creatorcontrib><creatorcontrib>Otsuka, Kuniaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Ram B.</au><au>Pella, Daniel</au><au>Sharma, Jagdish P.</au><au>Rastogi, Saurabh</au><au>Kartikey, Kumar</au><au>Goel, Vijay K.</au><au>Sharma, Rakesh</au><au>Neki, Narankar S.</au><au>Kumar, Adarsh</au><au>Otsuka, Kuniaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased concentrations of lipoprotein(a), circadian rhythms and metabolic reactions evoked by acute myocardial infarction, associated with acute reactions in relation to large breakfasts</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>58</volume><spage>S116</spage><epage>S122</epage><pages>S116-S122</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><coden>BIPHEX</coden><abstract>Of 54 patients with acute coronary artery disease (CAD) that were included in this study, 41 patients had acute myocardial infarction (AMI), five patients possible MI, four patients unstable angina and the remaining four angina pectoris. The control subjects (
n=85) were randomly selected from the general population of the city of Moradabad of similar age range after exclusion for CAD (
n=9), diabetes (
n=6) and excess intake of trans fatty acids (
n=20). The incidence of lipoprotein(a) excess (>30 mg/dl; 42.6 vs 24.7%;
P<0.05) and mean concentration of lipoprotein(a) (Lp[a], 6.4 mg/dl, 95% confidence interval: 2.8–10.5;
P<0.05) was significantly greater in the acute CAD group compared with control subjects. Mean total cholesterol and triglycerides were significantly higher and mean nitrite level lower in the study group as compared with the control group. There was a significant greater incidence of cardiac events in the second quarter of the day compared with the fourth quarter. Lp(a), triglycerides, blood glucose, plasma insulin, malondialdehyde, diene conjugates, TBARS and TNF-alpha and IL-6 levels, which were significantly greater during the acute phase, showed a significant decline and serum nitrite and coenzyme Q demonstrated an increase at 4 weeks of follow-up when the acute reactions evoked by MI had been controlled. Large breakfasts were a predisposing factor for cardiac events in the second quarter of the day and it was significantly associated with metabolic reactions. The findings indicate that acute reactions as a result or as circadian rhythms appear to be important in the pathogenesis of AMI-associated complications and that a large breakfast in association with nitrite deficiency may further trigger the circadian rhythms. However, more studies in a larger number of subjects would be necessary in order to confirm our findings.</abstract><cop>Paris</cop><pub>Elsevier SAS</pub><pmid>15754849</pmid><doi>10.1016/S0753-3322(04)80019-2</doi></addata></record> |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Acute Disease Biological and medical sciences Biotransformation Blood Glucose Cardiac event Cholesterol - blood Circadian rhythm Circadian Rhythm - physiology Coenzyme Q Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - diagnosis Cytokines Diet - adverse effects Diet - methods Glucose Humans India - ethnology Insulin Large breakfast Lipoprotein(a) Lipoproteins - blood Male Medical sciences Middle Aged Myocardial Infarction - complications Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Nitric oxide Nitrite Pharmacology. Drug treatments Total cholesterol Triglycerides - blood |
| title | Increased concentrations of lipoprotein(a), circadian rhythms and metabolic reactions evoked by acute myocardial infarction, associated with acute reactions in relation to large breakfasts |
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