Sympathoadrenal system under conditions of increased left and right ventricular afterload

Adrenergic plexuses in the myocardium and adrenal medulla were studied histochemically under conditions of increased left or right ventricular afterload. Under conditions of high afterload not accompanied by heart failure the density of sympathetic myocardial innervation remained unchanged in the lo...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-11, Vol.138 (5), p.529-531
Main Authors: Tverskaya, M S, Mishnev, O D, Karpova, V V, Izmailova, N S, Chumakova, M A, Virganskii, A O, Kadyrova, M Kh, Abdulkerimova, N Z, Bobrova, N A
Format: Article
Language:English
Subjects:
Adrenal Glands - innervation
Animals
Disease Models, Animal
Guinea Pigs
Sympathetic Nervous System - physiopathology
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Right - physiopathology
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Summary:Adrenergic plexuses in the myocardium and adrenal medulla were studied histochemically under conditions of increased left or right ventricular afterload. Under conditions of high afterload not accompanied by heart failure the density of sympathetic myocardial innervation remained unchanged in the loaded ventricle, but increased in the intact ventricle. Comparison of the state of the sympathoadrenal system under conditions of increased afterload complicated or uncomplicated by heart failure revealed common prognostically unfavorable changes: sharp decrease in the density of adrenergic nerve plexuses in the ventricular myocardium and activation of adrenal chromaffin cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0088-6