The Effect of Age on Vitamin E Status, Metabolism, and Function: Metabolism as Assessed by Labeled Tocopherols

: The effects of age on vitamin E metabolism were studied in 97 healthy 20‐75‐year‐old male nonsmoking Austrian volunteers of the VITAGE project. After a single oral intake of 30 mg d6‐RRR‐α‐ and d2‐RRR‐γ‐tocopheryl acetate, blood and 24‐hour urine was collected. Deuterated tocopherols in plasma and...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-12, Vol.1031 (1), p.40-43
Main Authors: BRIGELIUS-FLOHÉ, REGINA, ROOB, JOHANNES M., TIRAN, BEATE, WUGA, SANDRA, RIBALTA, JOSEP, ROCK, EDMOND, WINKLHOFER-ROOB, BRIGITTE M.
Format: Article
Language:English
Subjects:
Absorption
Adult
Aged
Aging
alpha-Tocopherol - blood
alpha-Tocopherol - pharmacokinetics
alpha-Tocopherol - urine
Austria
Chromans - urine
Deuterium
gamma-Tocopherol - blood
gamma-Tocopherol - pharmacokinetics
gamma-Tocopherol - urine
Humans
Male
metabolism
Middle Aged
Nutritional Status
Propionates - urine
Tocopherols - metabolism
Tocopherols - pharmacokinetics
vitamin E
Vitamin E - metabolism
α-CEHCs
α-tocopherol
γ-CEHCs
γ-tocopherol
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Summary:: The effects of age on vitamin E metabolism were studied in 97 healthy 20‐75‐year‐old male nonsmoking Austrian volunteers of the VITAGE project. After a single oral intake of 30 mg d6‐RRR‐α‐ and d2‐RRR‐γ‐tocopheryl acetate, blood and 24‐hour urine was collected. Deuterated tocopherols in plasma and deuterated urinary metabolites were analyzed by GC‐MS. A first evaluation revealed a similar uptake of d6‐α‐ and d2‐γ‐tocopherol during the first 6 hours, and then d2‐γ‐tocopherol started to decrease. Urinary d2‐γ‐ carboxyethyl hydroxychroman metabolites (CEHCs) exceeded those of d6‐α‐CEHCs by about 10 times. There was no effect of age. Thus, there might be no need for a higher vitamin E intake for healthy elderly nonsmoking men.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1331.004