Variations in APOE Genotype Distribution in Children from Areas with Different Adult Cardiovascular Disease Mortality in Spain

We investigate whether a varying distribution of the APOE genotype could help explain regional differences in ischemic heart disease (IHD) mortality in Spain. APOE genotypes were examined by PCR in 1,274 randomly selected healthy children from four Spanish regions with different adult IHD mortality...

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Published in:Human biology 2004-08, Vol.76 (4), p.615-621
Main Authors: GARCÉS, C., CANTOS, M., BENAVENTE, M., GRANIZO, J.J., CANO, B., VITURRO, E., DE OYA, M.
Format: Article
Language:English
Subjects:
Adult
Alleles
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E - genetics
Atherosclerosis
Cardiovascular disease
Child
Child health
Children
Children & youth
Diseases
Epidemiology
Gene Frequency
Genetic aspects
Genetic diversity
Genetic Variation
Genotype
Genotype & phenotype
Genotypes
Heart disease
Human biology
Human genetics
Humans
Medical genetics
Mortality
Myocardial ischemia
Myocardial Ischemia - genetics
Myocardial Ischemia - mortality
Population genetics
Prevalence
Regional variation
Spain
Spain - epidemiology
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container_issue 4
container_start_page 615
container_title Human biology
container_volume 76
creator GARCÉS, C.
CANTOS, M.
BENAVENTE, M.
GRANIZO, J.J.
CANO, B.
VITURRO, E.
DE OYA, M.
description We investigate whether a varying distribution of the APOE genotype could help explain regional differences in ischemic heart disease (IHD) mortality in Spain. APOE genotypes were examined by PCR in 1,274 randomly selected healthy children from four Spanish regions with different adult IHD mortality rates (northwest and central Spain with low rates and southeast and southern Spain with high rates). In the population as a whole the prevalence of the higher risk APOE*3/*4 genotype is 16.8% and the prevalence of the AP0E*4 allele is 10.1%. In northwest Spain the frequencies of the APOE*3/*4 genotype (12.9%) and of the APOE*4 allele (8.3%) are smaller than in the other regions. The southeast region shows statistically higher frequencies of the APOE*3/*4 genotype (22.5%) and of the APOEH allele (13.2%) than in the other regions or in the group as a whole. We can conclude that Spain is not homogeneous in terms of APOE genotype distribution. Although the prevalence of the APOE*4 allele is generally low, there are areas with higher prevalence of the APOE*4 allele and a higher incidence of adult IHD mortality. This allows us to conclude that in Spain this genetic determinant can be associated with IHD mortality in relatively isolated populations.
doi_str_mv 10.1353/hub.2004.0055
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APOE genotypes were examined by PCR in 1,274 randomly selected healthy children from four Spanish regions with different adult IHD mortality rates (northwest and central Spain with low rates and southeast and southern Spain with high rates). In the population as a whole the prevalence of the higher risk APOE*3/*4 genotype is 16.8% and the prevalence of the AP0E*4 allele is 10.1%. In northwest Spain the frequencies of the APOE*3/*4 genotype (12.9%) and of the APOE*4 allele (8.3%) are smaller than in the other regions. The southeast region shows statistically higher frequencies of the APOE*3/*4 genotype (22.5%) and of the APOEH allele (13.2%) than in the other regions or in the group as a whole. We can conclude that Spain is not homogeneous in terms of APOE genotype distribution. Although the prevalence of the APOE*4 allele is generally low, there are areas with higher prevalence of the APOE*4 allele and a higher incidence of adult IHD mortality. This allows us to conclude that in Spain this genetic determinant can be associated with IHD mortality in relatively isolated populations.</abstract><cop>United States</cop><pub>Wayne State University Press</pub><pmid>15754976</pmid><doi>10.1353/hub.2004.0055</doi><tpages>7</tpages></addata></record>
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subjects Adult
Alleles
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E - genetics
Atherosclerosis
Cardiovascular disease
Child
Child health
Children
Children & youth
Diseases
Epidemiology
Gene Frequency
Genetic aspects
Genetic diversity
Genetic Variation
Genotype
Genotype & phenotype
Genotypes
Heart disease
Human biology
Human genetics
Humans
Medical genetics
Mortality
Myocardial ischemia
Myocardial Ischemia - genetics
Myocardial Ischemia - mortality
Population genetics
Prevalence
Regional variation
Spain
Spain - epidemiology
title Variations in APOE Genotype Distribution in Children from Areas with Different Adult Cardiovascular Disease Mortality in Spain
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