Modulation of Cell Proliferation and Gene Expression by α-Tocopheryl Phosphates: Relevance to Atherosclerosis and Inflammation

: The effect of a mixture of α‐tocopheryl phosphate plus di‐α‐tocopheryl phosphate (TPm) was studied in vitro on two cell lines, RASMC (from rat aortic smooth muscle) and human THP‐1 monocytic leukemia cells. Inhibition of cell proliferation by TPm was shown in both lines and occurred with TPm at co...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-12, Vol.1031 (1), p.405-411
Main Authors: OGRU, ESRA, LIBINAKI, ROKSAN, GIANELLO, ROBERT, WEST, SIMON, MUNTEANU, ADELINA, ZINGG, JEAN-MARC, AZZI, ANGELO
Format: Article
Language:English
Subjects:
alpha-Tocopherol - analogs & derivatives
alpha-Tocopherol - pharmacology
Animals
Aorta
Apoptosis - drug effects
Arteriosclerosis
CD36 Antigens - genetics
Cell Division - drug effects
Cell Line
di-α-tocopheryl phosphate
Gene Expression - drug effects
Humans
Inflammation
Leukemia - pathology
Lipoproteins, LDL - metabolism
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - drug effects
Rats
THP-1 cells
Tumor Cells, Cultured
α-tocopheryl
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Summary:: The effect of a mixture of α‐tocopheryl phosphate plus di‐α‐tocopheryl phosphate (TPm) was studied in vitro on two cell lines, RASMC (from rat aortic smooth muscle) and human THP‐1 monocytic leukemia cells. Inhibition of cell proliferation by TPm was shown in both lines and occurred with TPm at concentrations lower than those at which α‐tocopherol was equally inhibitory. TPm led in nonstimulated THP‐1 cells to inhibition of CD36 mRNA and protein expression, to inhibition of oxidized low‐density lipoprotein surface binding and oxLDL uptake. In nonstimulated THP‐1 cells, α‐tocopherol had only very weak effects on these events.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1331.058