Course and outcome of a voltage-gated potassium channel antibody negative Morvan’s syndrome

Morvan’s syndrome is a rare disease characterized by peripheral nerve hyperexcitability, associated with CNS and autonomic systems involvement. High serum voltage-gated potassium channel (VGKC) antibody titers have been reported, and, till now, Morvan’s syndrome has been considered as a VGKC antibod...

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Bibliographic Details
Published in:Neurological sciences 2009-06, Vol.30 (3), p.237-239
Main Authors: Rinaldi, Carlo, Russo, Cinzia Valeria, Filla, Alessandro, De Michele, Giuseppe, Marano, Enrico
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Autoantibodies - blood
Case Report
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Myasthenia Gravis - blood
Myasthenia Gravis - complications
Myasthenia Gravis - immunology
Myokymia - blood
Myokymia - complications
Myokymia - drug therapy
Myokymia - immunology
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Plasma Exchange
Potassium Channels, Voltage-Gated - immunology
Prednisone - therapeutic use
Psychiatry
Ryanodine Receptor Calcium Release Channel - immunology
Treatment Outcome
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Summary:Morvan’s syndrome is a rare disease characterized by peripheral nerve hyperexcitability, associated with CNS and autonomic systems involvement. High serum voltage-gated potassium channel (VGKC) antibody titers have been reported, and, till now, Morvan’s syndrome has been considered as a VGKC antibody associated disease. We describe a patient with Morvan’s syndrome associated with myasthenia gravis and a thymoma in his previous history, with surprisingly undetectable levels of VGKC antibodies. The clinical course is similar to those cases of Morvan’s syndrome with VGKC-Ab, except for the lack of response to plasma exchange, previously considered as the first choice treatment. Nevertheless, the good response to corticosteroids therapy and the association with myasthenia confirm an autoimmune origin of the disease.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-009-0041-y