Recipient Genotype Is a Predictor of Allograft Cytokine Expression and Outcomes After Pediatric Cardiac Transplantation

Objectives This study sought to investigate the influence of recipient renin-angiotensin-aldosterone system (RAAS) genotype on cardiac function, rejection, and outcomes after heart transplantation. Background The RAAS influences cardiac function and up-regulates inflammatory/immune pathways. Little...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2009-05, Vol.53 (20), p.1909-1917
Main Authors: Auerbach, Scott R., MD, Manlhiot, Cedric, BS, Reddy, Sushma, MD, Kinnear, Caroline, MS, Richmond, Marc E., MD, Gruber, Dorota, MS, McCrindle, Brian W., MD, MPH, Deng, Liyong, MS, Chen, Jonathan M., MD, Addonizio, Linda J., MD, Chung, Wendy K., MD, Mital, Seema, MD
Format: Article
Language:English
Subjects:
Age
angiotensin
Biological and medical sciences
Biopsy
cardiac transplantation
Cardiology
Cardiology. Vascular system
Cardiomyopathies - surgery
Cardiovascular
Cardiovascular disease
Child
cytokines
Deoxyribonucleic acid
DNA
DNA - genetics
Drug therapy
Echocardiography
Enzymes
Ethnicity
Female
Follow-Up Studies
Gene Expression Regulation
Genes
genetics
Genotype
Genotype & phenotype
Graft Rejection - diagnosis
Graft Rejection - genetics
Graft Rejection - metabolism
Heart
Heart Defects, Congenital - surgery
Heart Transplantation
Humans
Interleukin-6 - biosynthesis
Interleukin-6 - genetics
Internal Medicine
Intubation
Male
Medical records
Medical sciences
Mortality
Myocardium - metabolism
Myocardium - pathology
Patients
Pediatrics
Polymerase Chain Reaction
Polymorphism
Pulmonary arteries
Retrospective Studies
Risk Factors
Rodents
Studies
Time Factors
Transforming Growth Factor alpha - biosynthesis
Transforming Growth Factor alpha - genetics
Transforming Growth Factor beta - biosynthesis
Transforming Growth Factor beta - genetics
Transplantation, Homologous
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Description
Summary:Objectives This study sought to investigate the influence of recipient renin-angiotensin-aldosterone system (RAAS) genotype on cardiac function, rejection, and outcomes after heart transplantation. Background The RAAS influences cardiac function and up-regulates inflammatory/immune pathways. Little is known about the effect of recipient RAAS polymorphisms in pediatric cardiac transplantation. Methods Patients
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2009.02.027