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γ-Tocotrienol Metabolism and Antiproliferative Effect in Prostate Cancer Cells

: In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl‐hydroxychromans metabolites (CEH...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-12, Vol.1031 (1), p.391-394
Main Authors: CONTE, CARMELA, FLORIDI, ALESSANDRO, AISA, CRISTINA, PIRODDI, MARTA, FLORIDI, ARDESIO, GALLI, FRANCESCO
Format: Article
Language:English
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Summary:: In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl‐hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude α‐T
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1331.054