The CULt of Caspase-8 Ubiquitination

Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.

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Bibliographic Details
Published in:Cell 2009-05, Vol.137 (4), p.604-606
Main Authors: Békés, Miklós, Salvesen, Guy S.
Format: Article
Language:English
Subjects:
Apoptosis
Caspase 8 - metabolism
Cullin Proteins - metabolism
Death Domain Receptor Signaling Adaptor Proteins - metabolism
Humans
Ubiquitination
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Description
Summary:Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.04.052