Medullary Thyroid Carcinoma and Tuberous Sclerosis

Medullary thyroid carcinoma (MTC) is a rare tumor and accounts for 5–10% of thyroid cancers. Tuberous sclerosis (TS) is a complex autosomal dominant neurocutaneous syndrome. In literature, a few endocrine neoplasias have been reported in association with TS, but never a case of TS associated with sp...

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Bibliographic Details
Published in:Endocrine pathology 2009-06, Vol.20 (2), p.141-144
Main Authors: Dicorato, Palma, Calvanese, Anna, Maiuolo, Amelia, D’Alessandri, Mimma, Grani, Giorgio, Ruggieri, Massimo, Fumarola, Angela
Format: Article
Language:English
Subjects:
Biopsy, Fine-Needle
Carcinoma - complications
Carcinoma - diagnosis
Endocrinology
Humans
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple Endocrine Neoplasia
Neck
Oncology
Pathology
Thyroid gland
Thyroid Neoplasms - complications
Thyroid Neoplasms - diagnosis
Tuberous Sclerosis - complications
Ultrasonography
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Summary:Medullary thyroid carcinoma (MTC) is a rare tumor and accounts for 5–10% of thyroid cancers. Tuberous sclerosis (TS) is a complex autosomal dominant neurocutaneous syndrome. In literature, a few endocrine neoplasias have been reported in association with TS, but never a case of TS associated with sporadic MTC. We describe a unique case, which has never been reported previously, of MTC associated with TS. The MTC up to today has been associated with other endocrine neoplasia, and TS increases risk of neoplasia in various organs. The case reported shows one more circumstance and suggests thyroid screening in patients with diagnosis of TS.
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-009-9077-z