Medullary Thyroid Carcinoma and Tuberous Sclerosis

Medullary thyroid carcinoma (MTC) is a rare tumor and accounts for 5–10% of thyroid cancers. Tuberous sclerosis (TS) is a complex autosomal dominant neurocutaneous syndrome. In literature, a few endocrine neoplasias have been reported in association with TS, but never a case of TS associated with sp...

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Published in:Endocrine pathology 2009-06, Vol.20 (2), p.141-144
Main Authors: Dicorato, Palma, Calvanese, Anna, Maiuolo, Amelia, D’Alessandri, Mimma, Grani, Giorgio, Ruggieri, Massimo, Fumarola, Angela
Format: Article
Language:English
Subjects:
Biopsy, Fine-Needle
Carcinoma - complications
Carcinoma - diagnosis
Endocrinology
Humans
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple Endocrine Neoplasia
Neck
Oncology
Pathology
Thyroid gland
Thyroid Neoplasms - complications
Thyroid Neoplasms - diagnosis
Tuberous Sclerosis - complications
Ultrasonography
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cited_by cdi_FETCH-LOGICAL-c435t-cd0df2c519852e963f430b32bbf1284569a8c86d94dc30b1fb8a44171fd07c203
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container_end_page 144
container_issue 2
container_start_page 141
container_title Endocrine pathology
container_volume 20
creator Dicorato, Palma
Calvanese, Anna
Maiuolo, Amelia
D’Alessandri, Mimma
Grani, Giorgio
Ruggieri, Massimo
Fumarola, Angela
description Medullary thyroid carcinoma (MTC) is a rare tumor and accounts for 5–10% of thyroid cancers. Tuberous sclerosis (TS) is a complex autosomal dominant neurocutaneous syndrome. In literature, a few endocrine neoplasias have been reported in association with TS, but never a case of TS associated with sporadic MTC. We describe a unique case, which has never been reported previously, of MTC associated with TS. The MTC up to today has been associated with other endocrine neoplasia, and TS increases risk of neoplasia in various organs. The case reported shows one more circumstance and suggests thyroid screening in patients with diagnosis of TS.
doi_str_mv 10.1007/s12022-009-9077-z
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source Springer Nature
subjects Biopsy, Fine-Needle
Carcinoma - complications
Carcinoma - diagnosis
Endocrinology
Humans
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple Endocrine Neoplasia
Neck
Oncology
Pathology
Thyroid gland
Thyroid Neoplasms - complications
Thyroid Neoplasms - diagnosis
Tuberous Sclerosis - complications
Ultrasonography
title Medullary Thyroid Carcinoma and Tuberous Sclerosis
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