Differential diagnosis of cholestasis following allogeneic hematopoietic stem cell transplantation in children: the contribution of serum bile acid levels in relation to other liver function tests

Hepatic complications associated with cholestasis occur frequently in hematopoietic stem cell transplant recipients. Since bile acid seems to be a sensitive indicator of beginning cholestasis, the authors monitored total serum bile acid levels in addition to the standard liver function tests in 23 r...

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Bibliographic Details
Published in:Pediatric hematology and oncology 2004-12, Vol.21 (8), p.697-705
Main Authors: Zakrzewski, J L, Ballauff, A, Wieland, R, Basu, O, Kremens, B
Format: Article
Language:English
Subjects:
Adolescent
Bile Acids and Salts - blood
Bilirubin - blood
Biomarkers - blood
Child
Child, Preschool
Cholestasis - diagnosis
Diagnosis, Differential
Female
Graft vs Host Disease - pathology
Hematologic Diseases - complications
Hematologic Diseases - therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Infant
Liver Diseases - etiology
Liver Function Tests
Male
Prospective Studies
Sensitivity and Specificity
Transplantation, Homologous
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Summary:Hepatic complications associated with cholestasis occur frequently in hematopoietic stem cell transplant recipients. Since bile acid seems to be a sensitive indicator of beginning cholestasis, the authors monitored total serum bile acid levels in addition to the standard liver function tests in 23 recipients of allogeneic transplants between June 1999 and September 2000. The observations suggest that bile acid is an early and sensitive marker of hepatic GvHD but not as specific as bilirubin. For cholestasis in absence of hepatic GvHD bile acid seems to be more sensitive than bilirubin. Routinely monitoring of bile acid after hematopoietic stem cell transplantation is not indicated.
ISSN:0888-0018
DOI:10.1080/08880010490514741