Importation and co-circulation of multiple serotypes of dengue virus in Sarawak, Malaysia

Although dengue is a common disease in South-East Asia, there is a marked absence of virological data from the Malaysian state of Sarawak located on the island of Borneo. From 1997 to 2002 we noted the co-circulation of DENV-2, DENV-3 and DENV-4 in Sarawak. To determine the origins of these Sarawak...

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Bibliographic Details
Published in:Virus research 2009-07, Vol.143 (1), p.1-5
Main Authors: Holmes, Edward C., Tio, Phaik-Hooi, Perera, David, Muhi, Jamail, Cardosa, Jane
Format: Article
Language:English
Subjects:
Dengue
Dengue - epidemiology
Dengue - virology
Dengue virus
Dengue Virus - classification
Dengue Virus - genetics
Dengue Virus - isolation & purification
Epidemiology
Evolution
Evolution, Molecular
Genetic Variation
Humans
Malaysia - epidemiology
Molecular Epidemiology
Phylogeny
RNA, Viral - analysis
RNA, Viral - genetics
Sarawak
Sequence Analysis, DNA
Serotyping
South-East Asia
Viral Envelope Proteins - analysis
Viral Envelope Proteins - genetics
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Summary:Although dengue is a common disease in South-East Asia, there is a marked absence of virological data from the Malaysian state of Sarawak located on the island of Borneo. From 1997 to 2002 we noted the co-circulation of DENV-2, DENV-3 and DENV-4 in Sarawak. To determine the origins of these Sarawak viruses we obtained the complete E gene sequences of 21 isolates. A phylogenetic analysis revealed multiple entries of DENV-2 and DENV-4 into Sarawak, such that multiple lineages co-circulate, yet with little exportation from Sarawak. Notably, all viral isolates were most closely related to those circulating in different localities in South-East Asia. In sum, our analysis reveals a frequent traffic of DENV in South-East Asia, with Sarawak representing a local sink population.
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2009.02.020