Risk and outcome analysis of renal replacement therapies in patients after cardiac surgery with pre‐operatively normal renal function

• Published in: Anaesthesia 2009-06, Vol.64 (6), p.615-619
• Main Authors: Hauer, D., Kilger, E., Kaufmann, I., Kreth, S., Beiras‐Fernandez, A., Briegel, J., Schelling, G., Schmidt, M., Weis, F.
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - etiology; Acute Kidney Injury - therapy; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Bilirubin - blood; Biological and medical sciences; Biomarkers - blood; Cardiac Surgical Procedures - adverse effects; Cardiopulmonary Bypass - adverse effects; Female; Heart surgery; Humans; Kidney - physiology; Kidney diseases; Lactic Acid - blood; Male; Medical sciences; Middle Aged; Postoperative period; Prospective Studies; Renal Replacement Therapy; Risk Factors; Treatment Outcome
• ISSN: 0003-2409; 1365-2044
• DOI: 10.1111/j.1365-2044.2009.05889.x

Summary Peri‐operative acute renal failure requiring renal replacement therapy is common (5–30%) after cardiac surgery and associated with a mortality of ∼50%. Pre‐operative renal impairment seems to be the most important risk factor for frank postoperative renal failure. To help evaluate the risk factors, we conducted a prospective observational trial of 1574 consecutive patients with normal pre‐operative renal function (creatinine  1.1 mmol.l−1 in the first 24 h after the operation was the strongest predictor for the development of renal failure.