Epidemiological characteristics of human herpesvirus-8 infection in a large population of antenatal women in Zambia

Comprehensive data describing epidemiological characteristics of the human herpesvirus‐8 or Kaposi's sarcoma‐associated herpesvirus (HHV‐8 or KSHV) infection among pregnant women in a central sub‐Saharan Africa are not available. This study determined virus prevalence estimates and the risk fac...

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Bibliographic Details
Published in:Journal of medical virology 2005-01, Vol.75 (1), p.93-100
Main Authors: Klaskala, W., Brayfield, B.P., Kankasa, C., Bhat, G., West, J.T., Mitchell, C.D., Wood, Charles
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Viral - blood
Biological and medical sciences
Condylomata Acuminata - complications
Condylomata Acuminata - epidemiology
Cross-Sectional Studies
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Herpesviridae Infections - epidemiology
Herpesvirus 8, Human - immunology
Herpesvirus 8, Human - isolation & purification
HHV-8 infection
HIV Antibodies - blood
HIV Infections - complications
HIV Infections - epidemiology
HIV-1 - isolation & purification
HIV-1 infection
Human viral diseases
Humans
Infectious diseases
Logistic Models
Medical sciences
Microbiology
Miscellaneous
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - virology
pregnant women
Prevalence
risk assessment
Risk Factors
Seroepidemiologic Studies
Sexual Behavior
Socioeconomic Factors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
Zambia
Zambia - epidemiology
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Summary:Comprehensive data describing epidemiological characteristics of the human herpesvirus‐8 or Kaposi's sarcoma‐associated herpesvirus (HHV‐8 or KSHV) infection among pregnant women in a central sub‐Saharan Africa are not available. This study determined virus prevalence estimates and the risk factors associated with HHV‐8 infection. Cross‐sectional, enrollment visit data were analyzed from a prospective cohort study of perinatal transmission of HHV‐8 in Lusaka, Zambia. Exposure data were obtained via structured interview, physical examination, medical chart review, and laboratory testing. Among 3,160 antenatal women serologically screened for HHV‐8 between September 1998 and October 2000, 40.2% were seropositive. The HHV‐8 positive women were more likely to be co‐infected with HIV‐1 than those who were HHV‐8 negative (34% vs. 26%; P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.20242