Cardiac Dysfunction Assessed by Echocardiographic Tissue Doppler Imaging Is an Independent Predictor of Mortality in the General Population

• Published in: Circulation (New York, N.Y.) N.Y.), 2009-05, Vol.119 (20), p.2679-2685
• Main Authors: MOGELVANG, Rasmus, SOGAARD, Peter, PEDERSEN, Sune A, OLSEN, Niels T, MAROTT, Jacob L, SCHNOHR, Peter, GOETZE, Jens P, JENSEN, Jan S
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Denmark - epidemiology; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Echocardiography, Doppler - methods; Echocardiography, Doppler - standards; Female; Follow-Up Studies; Heart Failure - diagnostic imaging; Heart Failure - epidemiology; Heart Failure - mortality; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Mortality; Prognosis; Proportional Hazards Models; Stroke Volume; Ultrasonic investigative techniques; Ventricular Dysfunction, Left
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circulationaha.108.793471

Tissue Doppler imaging (TDI) detects left ventricular dysfunction in patients with heart failure and normal ejection fraction, but the prognostic significance of left ventricular dysfunction by TDI in the general population is unknown. Within the Copenhagen City Heart Study, a large community-based population study, cardiac function was evaluated in 1036 participants by both conventional echocardiography and TDI. Averages of peak systolic (s'), early diastolic (e'), and late diastolic (a') velocities from 6 mitral annular sites were used. TDI was furthermore quantified by a combined index (eas index) of diastolic and systolic performance: e'/(a' x s'). During follow-up (median, 5.3 years), 90 participants died. Left ventricular dysfunction by TDI, in terms of low s' (hazard ratio, 1.23 per 1-cm/s decrease; P