Nasal Sumatriptan as Adjunctive Therapy for idiopathic Trigeminal Neuralgia: Report of Three Cases

We examine the effect of nasal sumatriptan as an adjunctive therapy in 3 patients with idiopathic trigeminal neuralgia refractory to carbamazepine (CBZ) and found that this therapy might be suitable for patients for whom the CBZ dose cannot be increased, who are under poor pain control, and who are...

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Bibliographic Details
Published in:Headache 2009-05, Vol.49 (5), p.768-770
Main Authors: Shimohata, Keiko, Shimohata, Takayoshi, Motegi, Ryoichiro, Miyashita, Kou
Format: Article
Language:English
Subjects:
adjunctive therapy
Administration, Intranasal
Aged
Anticonvulsants - administration & dosage
Biological and medical sciences
Carbamazepine - administration & dosage
Cardiovascular system
Dose-Response Relationship, Drug
Drug Resistance - physiology
Drug Therapy, Combination
Female
Humans
idiopathic trigeminal neuralgia
Medical sciences
Middle Aged
nasal sumatriptan
Neurogenic Inflammation - drug therapy
Neurogenic Inflammation - physiopathology
Neurology
Neuropeptides - antagonists & inhibitors
Neuropeptides - metabolism
Neuropeptides - secretion
Pharmacology. Drug treatments
Serotonin Receptor Agonists - administration & dosage
Sumatriptan - administration & dosage
Treatment Outcome
Trigeminal Nerve - drug effects
Trigeminal Nerve - metabolism
Trigeminal Nerve - physiopathology
Trigeminal Neuralgia - drug therapy
Trigeminal Neuralgia - physiopathology
Vascular diseases and vascular malformations of the nervous system
Vasodilator agents. Cerebral vasodilators
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Description
Summary:We examine the effect of nasal sumatriptan as an adjunctive therapy in 3 patients with idiopathic trigeminal neuralgia refractory to carbamazepine (CBZ) and found that this therapy might be suitable for patients for whom the CBZ dose cannot be increased, who are under poor pain control, and who are not candidates for nerve blocks or surgery.
ISSN:0017-8748
1526-4610
DOI:10.1111/j.1526-4610.2008.01254.x