Comparison of New Measures of Vascular Function to Flow Mediated Dilatation as a Measure of Cardiovascular Risk Factors

• Published in: The American journal of cardiology 2009-06, Vol.103 (11), p.1610-1615
• Main Authors: Philpott, Andrew C., MD, Lonn, Eva, MD, Title, Lawrence M., MD, Verma, Subodh, MD, PhD, Buithieu, Jean, MD, Charbonneau, Francois, MD, Anderson, Todd J., MD
• Format: Article
• Language: English
• Subjects: Ability grouping; Adult; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood pressure; Brachial Artery - physiology; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cholesterol, LDL - analysis; Endothelium, Vascular - physiology; Forearm - blood supply; Humans; Hyperemia - physiopathology; Linear Models; Low density lipoprotein; Male; Medical sciences; Middle Aged; Regional Blood Flow - physiology; Risk Factors; Stress, Mechanical; Vascular Resistance - physiology; Vasodilation - physiology
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2009.01.376

Although flow-mediated dilatation (FMD) is widely used, the ideal vascular parameter for the measurement of cardiovascular risk is not clear. Recently, it has been proposed that shear stress and blood velocity during hyperemia (VRH) may provide stronger correlations with cardiovascular risk factors than FMD. The aim of this study was to evaluate the relations of VRH and shear stress during reactive hyperemia (SSRH) to FMD and the association of these measures to cardiovascular risk factors in 1,477 men without cardiovascular disease. SSRH and VRH showed weak correlations with FMD in bivariate analysis (r = 0.239, p