Covalent surface modification of titanium oxide with different adhesive peptides: Surface characterization and osteoblast-like cell adhesion

A fundamental goal in the field of implantology is the design of innovative devices suitable for promoting implant‐to‐tissue integration. This result can be achieved by means of surface modifications aimed at optimizing tissue regeneration. In the framework of oral and orthopedic implantology, surfa...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2009-07, Vol.90A (1), p.35-45
Main Authors: Dettin, Monica, Bagno, Andrea, Gambaretto, Roberta, Iucci, Giovanna, Conconi, Maria Teresa, Tuccitto, Nunzio, Menti, Anna Michela, Grandi, Claudio, Di Bello, Carlo, Licciardello, Antonino, Polzonetti, Giovanni
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
biomaterial
biomimetic surface
Cell Adhesion
Cells, Cultured
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - metabolism
Endothelial Cells - cytology
Endothelial Cells - metabolism
Female
Humans
Materials Testing
Molecular Sequence Data
Molecular Structure
Osteoblasts - cytology
Osteoblasts - metabolism
peptide
Peptides - chemistry
Peptides - genetics
Peptides - metabolism
Rats
Rats, Sprague-Dawley
Silanes - chemistry
Spectrometry, Mass, Secondary Ion
surface characterization
Surface Properties
Titanium - chemistry
Titanium - metabolism
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Summary:A fundamental goal in the field of implantology is the design of innovative devices suitable for promoting implant‐to‐tissue integration. This result can be achieved by means of surface modifications aimed at optimizing tissue regeneration. In the framework of oral and orthopedic implantology, surface modifications concern both the optimization of titanium/titanium alloy surface roughness and the attachment of biochemical factors able to guide cellular adhesion and/or growth. This article focuses on the covalent attachment of two different adhesive peptides to rough titanium disks. The capability of biomimetic surfaces to increase osteoblast adhesion and the specificity of their biological activity due to the presence of cell adhesion signal‐motif have also been investigated. In addition, surface analyses by profilometry, X‐ray photoelectron spectroscopy, and time of flight‐secondary ion mass spectrometry have been carried out to investigate the effects and modifications induced by grafting procedures. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.32064