The linear noise approximation for molecular fluctuations within cells

We study the applicability of Van Kampen's linear noise approximation to the calculation of fluctuations in cells due to small number of molecules for simple genetic systems not previously considered. These systems include dimer formation and feedback. We explain why the linear noise approximat...

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Bibliographic Details
Published in:Physical biology 2004-12, Vol.1 (3-4), p.205-210
Main Authors: Hayot, F, Jayaprakash, C
Format: Article
Language:English
Subjects:
Cells
Dimerization
Models, Molecular
Proteins - chemistry
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Summary:We study the applicability of Van Kampen's linear noise approximation to the calculation of fluctuations in cells due to small number of molecules for simple genetic systems not previously considered. These systems include dimer formation and feedback. We explain why the linear noise approximation can be surprisingly effective, but also illustrate how it fails in a simple example when a protein probability distribution is not purely Gaussian.
ISSN:1478-3975
1478-3967
1478-3975
DOI:10.1088/1478-3967/1/4/002