Leukoplakia of oral mucosa: pathogenesis and possible correction with phytoadaptogen

Leukoplakia of the oral mucosa is characterized by impairment of the epithelial differentiation program. The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-12, Vol.138 (6), p.578-583
Main Authors: Bocharova, O A, Pozharitskaya, M M, Chekalina, T L, Lyzhenkova, M A, Karpova, R V, Mezentseva, M V, Ershov, F I
Format: Article
Language:English
Subjects:
Adult
Cell Adhesion Molecules - physiology
Female
Fluorescent Antibody Technique
Humans
Leukoplakia - drug therapy
Leukoplakia - immunology
Leukoplakia - physiopathology
Male
Middle Aged
Plant Extracts - therapeutic use
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Summary:Leukoplakia of the oral mucosa is characterized by impairment of the epithelial differentiation program. The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of immune effectors. The clinical effect manifested in involution or shrinkage and loosening of the pathological focus and complete epithelialization of erosive surfaces. The phytopreparation exhibited adaptogenic effects normalizing the immune and IFN status and improving the state of adaptation systems in the body.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0132-6