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Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction
Study Objective. To determine the effects of hawthorn (Crataegus oxycantha) on left ventricular remodeling and function in pressure overload‐induced heart failure in an animal model. Design. Randomized, parallel, dose‐ranging animal study. Setting. University research facility. Animals. Seventy‐four...
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| Published in: | Pharmacotherapy 2009-06, Vol.29 (6), p.639-648 |
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| creator | Hwang, Hyun Seok Boluyt, Marvin O. Converso, Kimber Russell, Mark W. Bleske, Barry E. |
| description | Study Objective. To determine the effects of hawthorn (Crataegus oxycantha) on left ventricular remodeling and function in pressure overload‐induced heart failure in an animal model.
Design. Randomized, parallel, dose‐ranging animal study.
Setting. University research facility.
Animals. Seventy‐four male Sprague‐Dawley rats; 44 were included in the final analysis.
Intervention. Rats underwent a sham operation or aortic constriction. Rats subjected to the sham operation were treated with vehicle (10% agar‐agar), and those subjected to aortic constriction were treated with vehicle or hawthorn (C. oxycantha special extract WS 1442) 1.3, 13, or 130 mg/kg for 5 months.
Measurements and Main Results. Rats and their hearts were weighed, and echocardiographic measurements were performed at baseline and at 2, 3, 4, and 5 months after aortic constriction. Protein expression for markers of fibrosis and for atrial natriuretic factor was also measured. Aortic constriction increased the left ventricular:body weight ratio by 53% in vehicle‐treated rats; Hawthorn treatment did not significantly affect the aortic constriction‐induced increase in this ratio. Left ventricular volumes and dimensions at systole and diastole significantly increased 5 months after aortic constriction compared with baseline in rats given vehicle (> 20% increase, p |
| doi_str_mv | 10.1592/phco.29.6.639 |
| format | article |
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Design. Randomized, parallel, dose‐ranging animal study.
Setting. University research facility.
Animals. Seventy‐four male Sprague‐Dawley rats; 44 were included in the final analysis.
Intervention. Rats underwent a sham operation or aortic constriction. Rats subjected to the sham operation were treated with vehicle (10% agar‐agar), and those subjected to aortic constriction were treated with vehicle or hawthorn (C. oxycantha special extract WS 1442) 1.3, 13, or 130 mg/kg for 5 months.
Measurements and Main Results. Rats and their hearts were weighed, and echocardiographic measurements were performed at baseline and at 2, 3, 4, and 5 months after aortic constriction. Protein expression for markers of fibrosis and for atrial natriuretic factor was also measured. Aortic constriction increased the left ventricular:body weight ratio by 53% in vehicle‐treated rats; Hawthorn treatment did not significantly affect the aortic constriction‐induced increase in this ratio. Left ventricular volumes and dimensions at systole and diastole significantly increased 5 months after aortic constriction compared with baseline in rats given vehicle (> 20% increase, p<0.05) but not in those given hawthorn 130 mg/kg (< 10% increase). After aortic constriction, the velocity of circumferential shortening significantly decreased in the vehicle group but not in the medium‐ or high‐dose groups. In the aortic constriction‐vehicle group, the induced increases in messenger RNA expression for atrial natriuretic factor (∼1000%) and fibronectin (∼80%) were significantly attenuated by highdose hawthorn treatment by approximately 80% and 50%, respectively.
Conclusion. Hawthorn treatment exhibited modest beneficial effects on cardiac remodeling and function during long‐term, pressure overload‐induced heart failure in rats.</description><identifier>ISSN: 0277-0008</identifier><identifier>EISSN: 1875-9114</identifier><identifier>DOI: 10.1592/phco.29.6.639</identifier><identifier>PMID: 19476417</identifier><identifier>CODEN: PHPYDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ANF ; animal study ; Animals ; Aorta - physiopathology ; atrial natriuretic factor ; Atrial Natriuretic Factor - metabolism ; Biological and medical sciences ; Biomarkers - metabolism ; Cardiology. Vascular system ; Constriction, Pathologic - complications ; Crataegus - chemistry ; Crataegus oxycantha ; Disease Models, Animal ; Disease Progression ; Dose-Response Relationship, Drug ; Echocardiography ; fibronectin ; Fibronectins - metabolism ; hawthorn ; Heart ; heart failure ; Heart Failure - drug therapy ; Heart Failure - etiology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Hypertrophy, Left Ventricular - drug therapy ; left ventricular volume ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - therapeutic use ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - metabolism ; Time Factors ; Ventricular Remodeling - drug effects</subject><ispartof>Pharmacotherapy, 2009-06, Vol.29 (6), p.639-648</ispartof><rights>2009 Pharmacotherapy Publications Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4422-c39365bd88845be2d3df9b84da543a16a6ba1cd7e430991c87ce8a68dc2fd0e33</citedby><cites>FETCH-LOGICAL-c4422-c39365bd88845be2d3df9b84da543a16a6ba1cd7e430991c87ce8a68dc2fd0e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21549463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19476417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Hyun Seok</creatorcontrib><creatorcontrib>Boluyt, Marvin O.</creatorcontrib><creatorcontrib>Converso, Kimber</creatorcontrib><creatorcontrib>Russell, Mark W.</creatorcontrib><creatorcontrib>Bleske, Barry E.</creatorcontrib><title>Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction</title><title>Pharmacotherapy</title><addtitle>Pharmacotherapy</addtitle><description>Study Objective. To determine the effects of hawthorn (Crataegus oxycantha) on left ventricular remodeling and function in pressure overload‐induced heart failure in an animal model.
Design. Randomized, parallel, dose‐ranging animal study.
Setting. University research facility.
Animals. Seventy‐four male Sprague‐Dawley rats; 44 were included in the final analysis.
Intervention. Rats underwent a sham operation or aortic constriction. Rats subjected to the sham operation were treated with vehicle (10% agar‐agar), and those subjected to aortic constriction were treated with vehicle or hawthorn (C. oxycantha special extract WS 1442) 1.3, 13, or 130 mg/kg for 5 months.
Measurements and Main Results. Rats and their hearts were weighed, and echocardiographic measurements were performed at baseline and at 2, 3, 4, and 5 months after aortic constriction. Protein expression for markers of fibrosis and for atrial natriuretic factor was also measured. Aortic constriction increased the left ventricular:body weight ratio by 53% in vehicle‐treated rats; Hawthorn treatment did not significantly affect the aortic constriction‐induced increase in this ratio. Left ventricular volumes and dimensions at systole and diastole significantly increased 5 months after aortic constriction compared with baseline in rats given vehicle (> 20% increase, p<0.05) but not in those given hawthorn 130 mg/kg (< 10% increase). After aortic constriction, the velocity of circumferential shortening significantly decreased in the vehicle group but not in the medium‐ or high‐dose groups. In the aortic constriction‐vehicle group, the induced increases in messenger RNA expression for atrial natriuretic factor (∼1000%) and fibronectin (∼80%) were significantly attenuated by highdose hawthorn treatment by approximately 80% and 50%, respectively.
Conclusion. Hawthorn treatment exhibited modest beneficial effects on cardiac remodeling and function during long‐term, pressure overload‐induced heart failure in rats.</description><subject>ANF</subject><subject>animal study</subject><subject>Animals</subject><subject>Aorta - physiopathology</subject><subject>atrial natriuretic factor</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Constriction, Pathologic - complications</subject><subject>Crataegus - chemistry</subject><subject>Crataegus oxycantha</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Dose-Response Relationship, Drug</subject><subject>Echocardiography</subject><subject>fibronectin</subject><subject>Fibronectins - metabolism</subject><subject>hawthorn</subject><subject>Heart</subject><subject>heart failure</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - etiology</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Hypertrophy, Left Ventricular - drug therapy</subject><subject>left ventricular volume</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - therapeutic use</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - metabolism</subject><subject>Time Factors</subject><subject>Ventricular Remodeling - drug effects</subject><issn>0277-0008</issn><issn>1875-9114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kMtvEzEQxi0EoqFw5Ip8gdsGvx_HKGqbSn1EVREnZHltLzFs1qntqPS_Z1eJ2ltPo9H3m29mPgA-YzTHXJPvu41Lc6LnYi6ofgNmWEneaIzZWzBDRMoGIaROwIdS_iBEsGDkPTjBmknBsJyBX2ddF1wtMHVwZR_rJuUBpgHWTYDrnH7nUEoc-0kONld4bmO_zwHGAVp4Zyu8Tj70k75IuUYHl2koNUdXx7GP4F1n-xI-Hesp-HF-dr9cNVe3F5fLxVXjGCOkcVRTwVuvlGK8DcRT3-lWMW85oxYLK1qLnZeBUaQ1dkq6oKxQ3pHOo0DpKfh28N3l9LAPpZptLC70vR1C2hcjJEWYaDmCzQF0OZWSQ2d2OW5tfjIYmSlPM-VpiDbCjHmO_Jej8b7dBv9CHwMcga9HwBZn-y7bwcXyzBHMmWZiupAeuMfYh6fXt5r1anGHOSUv58ZSw7_nKZv_Ti9Jbn7eXBim-FpxxQ2l_wF6Up0t</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Hwang, Hyun Seok</creator><creator>Boluyt, Marvin O.</creator><creator>Converso, Kimber</creator><creator>Russell, Mark W.</creator><creator>Bleske, Barry E.</creator><general>Blackwell Publishing Ltd</general><general>Pharmacotherapy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction</title><author>Hwang, Hyun Seok ; Boluyt, Marvin O. ; Converso, Kimber ; Russell, Mark W. ; Bleske, Barry E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4422-c39365bd88845be2d3df9b84da543a16a6ba1cd7e430991c87ce8a68dc2fd0e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>ANF</topic><topic>animal study</topic><topic>Animals</topic><topic>Aorta - physiopathology</topic><topic>atrial natriuretic factor</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Constriction, Pathologic - complications</topic><topic>Crataegus - chemistry</topic><topic>Crataegus oxycantha</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Dose-Response Relationship, Drug</topic><topic>Echocardiography</topic><topic>fibronectin</topic><topic>Fibronectins - metabolism</topic><topic>hawthorn</topic><topic>Heart</topic><topic>heart failure</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - etiology</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Hypertrophy, Left Ventricular - drug therapy</topic><topic>left ventricular volume</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - therapeutic use</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - metabolism</topic><topic>Time Factors</topic><topic>Ventricular Remodeling - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Hyun Seok</creatorcontrib><creatorcontrib>Boluyt, Marvin O.</creatorcontrib><creatorcontrib>Converso, Kimber</creatorcontrib><creatorcontrib>Russell, Mark W.</creatorcontrib><creatorcontrib>Bleske, Barry E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Hyun Seok</au><au>Boluyt, Marvin O.</au><au>Converso, Kimber</au><au>Russell, Mark W.</au><au>Bleske, Barry E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction</atitle><jtitle>Pharmacotherapy</jtitle><addtitle>Pharmacotherapy</addtitle><date>2009-06</date><risdate>2009</risdate><volume>29</volume><issue>6</issue><spage>639</spage><epage>648</epage><pages>639-648</pages><issn>0277-0008</issn><eissn>1875-9114</eissn><coden>PHPYDQ</coden><abstract>Study Objective. To determine the effects of hawthorn (Crataegus oxycantha) on left ventricular remodeling and function in pressure overload‐induced heart failure in an animal model.
Design. Randomized, parallel, dose‐ranging animal study.
Setting. University research facility.
Animals. Seventy‐four male Sprague‐Dawley rats; 44 were included in the final analysis.
Intervention. Rats underwent a sham operation or aortic constriction. Rats subjected to the sham operation were treated with vehicle (10% agar‐agar), and those subjected to aortic constriction were treated with vehicle or hawthorn (C. oxycantha special extract WS 1442) 1.3, 13, or 130 mg/kg for 5 months.
Measurements and Main Results. Rats and their hearts were weighed, and echocardiographic measurements were performed at baseline and at 2, 3, 4, and 5 months after aortic constriction. Protein expression for markers of fibrosis and for atrial natriuretic factor was also measured. Aortic constriction increased the left ventricular:body weight ratio by 53% in vehicle‐treated rats; Hawthorn treatment did not significantly affect the aortic constriction‐induced increase in this ratio. Left ventricular volumes and dimensions at systole and diastole significantly increased 5 months after aortic constriction compared with baseline in rats given vehicle (> 20% increase, p<0.05) but not in those given hawthorn 130 mg/kg (< 10% increase). After aortic constriction, the velocity of circumferential shortening significantly decreased in the vehicle group but not in the medium‐ or high‐dose groups. In the aortic constriction‐vehicle group, the induced increases in messenger RNA expression for atrial natriuretic factor (∼1000%) and fibronectin (∼80%) were significantly attenuated by highdose hawthorn treatment by approximately 80% and 50%, respectively.
Conclusion. Hawthorn treatment exhibited modest beneficial effects on cardiac remodeling and function during long‐term, pressure overload‐induced heart failure in rats.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19476417</pmid><doi>10.1592/phco.29.6.639</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ANF animal study Animals Aorta - physiopathology atrial natriuretic factor Atrial Natriuretic Factor - metabolism Biological and medical sciences Biomarkers - metabolism Cardiology. Vascular system Constriction, Pathologic - complications Crataegus - chemistry Crataegus oxycantha Disease Models, Animal Disease Progression Dose-Response Relationship, Drug Echocardiography fibronectin Fibronectins - metabolism hawthorn Heart heart failure Heart Failure - drug therapy Heart Failure - etiology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hypertrophy, Left Ventricular - drug therapy left ventricular volume Male Medical sciences Pharmacology. Drug treatments Phytotherapy Plant Extracts - therapeutic use Random Allocation Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Time Factors Ventricular Remodeling - drug effects |
| title | Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction |
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