A 1 : 2 Copper(II)-Tripeptide Complex for DNA Binding and Cleavage Agent under Physiological Conditions

A 1 : 2 copper–tripeptide complex, [CuII(Boc‐His‐Gly‐His‐OMe)2]2+, was synthesized and structurally characterized. The absorption band at 577 nm suggests a square‐planar geometry around CuII. The DNA‐binding and DNA‐cleavage properties of the CuII complex were investigated. The complex binds to calf...

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Bibliographic Details
Published in:Chemistry & biodiversity 2009-05, Vol.6 (5), p.764-773
Main Authors: Reddy, Pulimamidi R., Manjula, Pallerla, Chakraborty, Tushar K., Samanta, Rajarshi
Format: Article
Language:English
Subjects:
Copper - chemistry
Copper complexes
DNA
DNA - chemistry
DNA Cleavage - drug effects
Intercalation
Kinetics
Oligopeptides - chemistry
Organometallic Compounds - chemistry
Peptides
Peptides - chemistry
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Summary:A 1 : 2 copper–tripeptide complex, [CuII(Boc‐His‐Gly‐His‐OMe)2]2+, was synthesized and structurally characterized. The absorption band at 577 nm suggests a square‐planar geometry around CuII. The DNA‐binding and DNA‐cleavage properties of the CuII complex were investigated. The complex binds to calf thymus DNA (CT DNA) in an intercalative fashion and cleaves plasmid pUC‐19 DNA hydrolytically at micromolar concentrations under physiological conditions. The intrinsic binding constant (Kb=1.2×102 M−1) for the binding of Cu–tripeptide complex with DNA suggests that this complex is suitable for rapid diffusion on the pharmacological time scale.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.200800079