Mannose-binding lectin in high-risk human papillomavirus infection

Objective Mannose-binding lectin (MBL) is a serum lectin that mediates phagocytosis and activates complement. We investigated the association of mbl -2 functional polymorphisms with human papillomavirus (HPV) infection, which is a primary etiologic factor for cervical cancer. Study Design The freque...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2009-06, Vol.200 (6), p.618.e1-618.e6
Main Authors: Tsai, Ching-Chou, MD, Lin, Tsun-Mei, PhD, You, Huey-Ling, PhD, Eng, Hock-Liew, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Female
Gynecology. Andrology. Obstetrics
HPV
Humans
infection
Mannose-Binding Lectin - genetics
MBL
Medical sciences
Middle Aged
Obstetrics and Gynecology
Papillomavirus Infections - genetics
polymorphism
Polymorphism, Genetic
Risk Factors
Young Adult
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Summary:Objective Mannose-binding lectin (MBL) is a serum lectin that mediates phagocytosis and activates complement. We investigated the association of mbl -2 functional polymorphisms with human papillomavirus (HPV) infection, which is a primary etiologic factor for cervical cancer. Study Design The frequencies of haplotypes and genotypes of mbl-2 exon1 and promoter region variants were analyzed in 150 patients with HPV and 277 control subjects with no HPV. Unconditional logistic regression analysis was performed to evaluate an association between specific mbl-2 alleles and susceptibility to HPV infection. Results The frequency of high-producer mbl -2 genotypes was higher in patients with HPV than in control subjects with no HPV ( P = .001). The genotype of the mbl-2 gene polymorphisms represented the least significant risk for the group with HPV. Conclusion Certain polymorphisms in the MBL promoter region are increased among cervical samples that demonstrate HPV infection. This finding suggests a potential link between MBL and high-risk HPV infection.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2009.02.016