The effect of cyanoacrylate in esophagocutaneous leakages occurring after esophageal anastomosis

Abstract Objective Esophageal leakage (EL) continues to be a challenging pediatric surgical problem. The aim of this study was to investigate the effect of cyanoacrylate (Cy) in EL followed esophageal repair (ER). Methods Twelve rabbits were divided into control (C) and leakage (L) groups. A 1 cm-le...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2009-07, Vol.73 (7), p.1053-1055
Main Authors: Yurtçu, Müslim, Arbag, Hamdi, Çağlayan, Osman, Abasiyanik, Adnan, Öz, Mehmet
Format: Article
Language:English
Subjects:
Anastomosis, Surgical - adverse effects
Animals
Cutaneous Fistula - drug therapy
Cutaneous Fistula - etiology
Cyanoacrylate glue
Cyanoacrylates - administration & dosage
Disease Models, Animal
Esophageal Fistula - drug therapy
Esophageal Fistula - etiology
Esophageal leakage
Esophageal repair
Esophagus - drug effects
Esophagus - surgery
Humans
Hydroxyproline - drug effects
Otolaryngology
Pediatrics
Rabbits
Tissue Adhesives - administration & dosage
Wound Healing - drug effects
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Summary:Abstract Objective Esophageal leakage (EL) continues to be a challenging pediatric surgical problem. The aim of this study was to investigate the effect of cyanoacrylate (Cy) in EL followed esophageal repair (ER). Methods Twelve rabbits were divided into control (C) and leakage (L) groups. A 1 cm-length transverse esophageal incision at the level of the cervical region was made. In both groups, feeding was started orally 24 h after the surgery for leakage creation. On postoperative day 7, primary repair was carried out in the C group and Cy instillation was performed in the L group. Esophagographic analysis was carried out on postoperative day 9 and the animals were fed orally on the same day on the condition that there was no esophageal leakage. The rabbits were sacrificed to measure diameters of the OR line, bursting pressure (BP), and hydroxyproline (HP) levels in the repaired cervical esophageal segment (RCES) 2 months later. Results The values of BP and HP in the C group were significantly higher than those in the L group. The diameters of the OR line in the L group were significantly greater compared to those in the C group. Conclusions Cy glue instillation seems to be the ideal treatment for esophageal anastomosis leakages as shown by increased diameters of the OR line and decreased HP levels.
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2009.04.013