Genetic variation in the interleukin-10 gene promoter in Polish patients with systemic lupus erythematosus

Identification of susceptibility genes in systemic lupus erythematosus (SLE) has recently become a topic of interest. The IL-10 promoter contains three single base-pair substitutions at −627C > A, −854C > T and −1117G > A. These single base-pair substitutions produce three different haploty...

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Bibliographic Details
Published in:Rheumatology international 2009-06, Vol.29 (8), p.921-925
Main Authors: Sobkowiak, Adam, Lianeri, Margarita, Wudarski, Mariusz, Łącki, Jan K., Jagodziński, Paweł P.
Format: Article
Language:English
Subjects:
Adult
Alleles
Autoimmune diseases
Base Pairing
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes
Heterozygote
Homozygote
Humans
Interleukin-10 - genetics
Interleukin-10 - immunology
Lupus
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Medicine
Medicine & Public Health
Middle Aged
Original Article
Poland
Polymorphism, Genetic
Promoter Regions, Genetic
Rheumatology
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Summary:Identification of susceptibility genes in systemic lupus erythematosus (SLE) has recently become a topic of interest. The IL-10 promoter contains three single base-pair substitutions at −627C > A, −854C > T and −1117G > A. These single base-pair substitutions produce three different haplotypes, GCC, ACC and ATA, which affect IL-10 expression. We examined the distribution of −627C > A, −854C > T and −1117G > A IL-10 promoter polymorphisms in patients with SLE ( n  = 103, women only) and matched controls ( n  = 300). Despite the higher prevalence of the GCC/GCC, GCC/ATA and ATA/ATA genotypes in SLE patients than in controls, we observed that only GCC/GCC genotype frequency distribution was significant between these groups. We observed that women with the GCC/GCC genotype displayed an approximately twofold increased risk of SLE OR = 2.245 (95% CI = 1.354–3.721, P  = 0.0022). We did not find any associations between various genotypes of IL-10 promoter haplotypes and clinical manifestations or autoantibody production in patients with SLE. Our observations indicate that the GCC/GCC promoter genotype may contribute to SLE incidence in Polish patients.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-008-0776-4