Hypertension and diabetes mellitus are associated with cardiovascular events in the elderly without cardiovascular disease. Results of a 15-year follow-up in a Mediterranean population

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2009-06, Vol.19 (5), p.321-326
• Main Authors: Noto, D, Cefalù, A.B, Barbagallo, C.M, Sapienza, M, Cavera, G, Nardi, I, Pagano, M, Vivona, N, Notarbartolo, A, Averna, M.R
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Cardiovascular; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Diabetes Complications; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - mortality; Elderly; Epidemiology; Female; Follow-Up Studies; Humans; Hypertension - blood; Hypertension - epidemiology; Hypertension - mortality; Incidence; Inflammation - blood; Italy - epidemiology; Lipids - blood; Male; Risk Factors; Survival Analysis
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2008.03.002

Abstract Background and aims Epidemiological prospective data on cardiovascular (CV) events in elderly subjects from Mediterranean populations are lacking. We aimed to investigate 15-year incidence of CV events and to evaluate the association with CV risk factors in an elderly Mediterranean population. Methods and results The population of a small Sicilian village were enrolled, visited and a blood sample was drawn at baseline. CV events were recorded in the 15 years of follow-up. From 1351 subjects (75% of the resident population); 315 were in the age range 65–85 years; 266 subjects free from CV disease were analysed. Seventy-seven CV events were recorded in 73 out of 266 subjects, with a 19.7% rate (in 10 years). Hypertension (HTN) (hazards ratio = 2.1) and diabetes mellitus (DM) (hazards ratio = 1.8) were independently associated with CV events. Subjects with both DM and HTN showed a lower survival free of CV events compared to those with DM or HTN. Conclusions In a 15-year follow-up of an elderly Mediterranean population free from CV disease, diabetes mellitus and hypertension were related to CV events. The control of risk factors in the elderly needs to be reinforced to achieve better results in terms of CV prevention.