Excitation and sensitization of nociceptors by bradykinin: what do we know?

Bradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of nociceptors is not well established. Prot...

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Bibliographic Details
Published in:Experimental brain research 2009-06, Vol.196 (1), p.53-65
Main Authors: Mizumura, Kazue, Sugiura, Takeshi, Katanosaka, Kimiaki, Banik, Ratan K, Kozaki, Yasuko
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Bradykinin - metabolism
Brain research
Esophagus
Hot Temperature
Humans
Hyperalgesia
Hyperalgesia - immunology
Hyperalgesia - physiopathology
Kinases
Models, Neurological
Neurogenic Inflammation - physiopathology
Neurology
Neurosciences
Nociceptors - immunology
Nociceptors - physiology
Pain - immunology
Pain - physiopathology
Pain Threshold - physiology
Physical Stimulation
Prostaglandins - metabolism
Protein Kinase C - metabolism
Proteins
Review
Signal transduction
TRPV Cation Channels - metabolism
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Summary:Bradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of nociceptors is not well established. Protein kinase C and TRPV1 contribute to the sensitizing mechanism of bradykinin to heat. In addition, TRPA1 and other ion channels appear to contribute to excitation caused by bradykinin. Finally, prostaglandins sensitize bradykinin-induced excitation in normal tissues by restoring desensitized responses due to the inhibition of protein kinase A.
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-009-1814-5