Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia

Naturally occurring dimeric 1,4-benzoquinone derivatives, belamcandaquinones F, G, H, and I, and a resorcinol derivative, as well as four known compounds, were isolated and identified from the rhizome of Ardisia gigantifolia. Cytotoxicity of each against cell lines PC-3, EMT6, A549, Hela, RM-1, and...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2009-04, Vol.70 (6), p.773-778
Main Authors: Liu, Hongwei, Zhao, Feng, Yang, Ruiyun, Wang, Manyuan, Zheng, Meiqing, Zhao, Yisong, Zhang, Xue, Qiu, Feng, Wang, Hengshan
Format: Article
Language:English
Subjects:
1,4-Benzoquinone derivative
anticarcinogenic activity
Ardisia
Ardisia - chemistry
Ardisia gigantifolia
belamcandaquinone
benzoquinones
Benzoquinones - chemistry
Benzoquinones - isolation & purification
Biological and medical sciences
Cell Line
Chemical constitution
chemical structure
Cytotoxicity
Dimerization
Fundamental and applied biological sciences. Psychology
human health
Magnetic Resonance Spectroscopy
medicinal plants
medicinal properties
Myrsinaceae
phytochemicals
Plant physiology and development
resorcinol
Resorcinol derivative
Resorcinols - chemistry
Resorcinols - isolation & purification
spectral analysis
Spectrometry, Mass, Electrospray Ionization
stereochemistry
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Summary:Naturally occurring dimeric 1,4-benzoquinone derivatives, belamcandaquinones F, G, H, and I, and a resorcinol derivative, as well as four known compounds, were isolated and identified from the rhizome of Ardisia gigantifolia. Cytotoxicity of each against cell lines PC-3, EMT6, A549, Hela, RM-1, and SGC7901 were tested in vitro. In comparison with cisplatin, compounds 5 and 6 showed a strong cytotoxicity with IC 50 values less than 30 μM for most cell lines tested. Naturally occurring dimeric 1,4-benzoquinone derivatives, belamcandaquinones F, G, H, and I, as well as one resorcinol derivative and four known compounds, were isolated from rhizomes of Ardisia gigantifolia. Their structures were established by means of spectroscopic analyses. All compounds were tested against cell lines PC-3, EMT6, A549, Hela, RM-1, and SGC7901 for cytotoxicity in vitro. In comparison with cisplatin, compounds 5 and 6 showed a strong cytotoxicity with IC 50 values less than 30 μM for most cell lines tested.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2009.04.004