Intravenous immunoglobulins in autoimmune and inflammatory disorders: beyond a simple substitution

Despite their widespread use since many years in autoimmune and inflammatory disorders, the mechanisms of action of IVIg have not been completely understood. These mechanisms depend on Fc and/or F(ab')2. IVIg interacts with the different components of the immune system: Fc receptors, complement...

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Bibliographic Details
Published in:Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2009-05, Vol.16 (2), p.75-79
Main Authors: Galeotti, C, Maddur, M S, Kazatchkine, M-D, Mouthon, L, Kaveri, S-V
Format: Article
Language:fre
Subjects:
Autoimmune Diseases - drug therapy
B-Lymphocytes - drug effects
Dendritic Cells - drug effects
Granulocytes - drug effects
Humans
Immunoglobulins, Intravenous - therapeutic use
Inflammation - drug therapy
Killer Cells, Natural - drug effects
Receptors, Fc - drug effects
T-Lymphocytes - drug effects
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Summary:Despite their widespread use since many years in autoimmune and inflammatory disorders, the mechanisms of action of IVIg have not been completely understood. These mechanisms depend on Fc and/or F(ab')2. IVIg interacts with the different components of the immune system: Fc receptors, complement, cytokines, T and B lymphocytes, dendritic cells, granulocytes and NK cells. Here, we discuss the recent advances in the understanding of the mechanisms of action of IVIg, in particular the importance of the sialylated Fc fragment. These advances maybe help us conceive better therapeutic strategies against autoimmune and inflammatory disorders.
ISSN:1246-7820
DOI:10.1016/j.tracli.2009.03.009