Th17 cells in rheumatoid arthritis and systemic lupus erythematosus

. Recent work has implicated a novel Th effector cell subset, the Th17 cell subset, in the development of both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) because of the ability of Th17 cells to produce cytokines like IL‐17 and IL‐21 that can drive both inflammatory and humoral...

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Bibliographic Details
Published in:Journal of internal medicine 2009-06, Vol.265 (6), p.644-652
Main Author: Pernis, A. B.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Biological and medical sciences
Cell Differentiation - immunology
Diseases of the osteoarticular system
Female
General aspects
Humans
Inflammatory joint diseases
interferon regulatory factor 4
Interleukin-17 - immunology
Interleukins - immunology
IRF‐4 binding protein
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
rheumatoid arthritis
Signal Transduction - immunology
systemic lupus erythematosus
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
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Summary:. Recent work has implicated a novel Th effector cell subset, the Th17 cell subset, in the development of both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) because of the ability of Th17 cells to produce cytokines like IL‐17 and IL‐21 that can drive both inflammatory and humoral responses. In this review, we will discuss recent studies that have begun elucidating the factors that regulate the development of Th17 cells and provide a brief overview of the role of Th17 cells in RA and SLE.
ISSN:0954-6820
1365-2796
DOI:10.1111/j.1365-2796.2009.02099.x