Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer

The sentinel lymph node (SLN) is regarded as the first tumor-draining lymph node, which may be the initial site activated by tumor antigens. To clarify the immunological functions of SLNs, a total of 89 tumor-free regional lymph nodes (41 SLNs and 48 non-SLNs) were obtained from 12 patients with ora...

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Bibliographic Details
Published in:Oral oncology 2005, Vol.41 (1), p.89-96
Main Authors: Sakakura, Koichi, Chikamatsu, Kazuaki, Sakurai, Tsutomu, Takahashi, Katsumasa, Murata, Takaaki, Oriuchi, Noboru, Furuya, Nobuhiko
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Cell Movement - immunology
Dendritic cells
Dendritic Cells - immunology
Female
Humans
Killer Cells, Natural - immunology
Lymph Nodes - immunology
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Mouth Neoplasms - immunology
Mouth Neoplasms - pathology
NK cells
Oral cavity cancer
Otorhinolaryngology. Stomatology
Sentinel Lymph Node Biopsy
Sentinel lymph nodes
Tumors
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Summary:The sentinel lymph node (SLN) is regarded as the first tumor-draining lymph node, which may be the initial site activated by tumor antigens. To clarify the immunological functions of SLNs, a total of 89 tumor-free regional lymph nodes (41 SLNs and 48 non-SLNs) were obtained from 12 patients with oral cavity cancer, and infiltration of both DCs and NK cells was determined by immunohistochemistry. S-100+ and CD1a+ DCs infiltrated significantly into SLNs compared to non-SLNs. Analysis in each of the pN0 and pN+ patients showed that all the DC markers in pN0 patients and only S-100+ in pN+ patients were significantly more abundant in SLNs. Moreover, infiltration of CD83+ DCs was less in pN+ patients than in pN0 patients. These results suggest that more significant immune responses against cancer occur in SLNs than in non-SLNs. However the progression of disease including nodal disease may cause systemic immunosuppression.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2004.07.004