Distinct but overlapping T helper epitopes in the 37–58 region of SSX-2

Because of their specific expression in tumors of different histological types, the products of the SSX genes are important candidate targets for development of cancer vaccines. We have previously identified two immunodominant SSX-2-derived T cell epitopes recognized by HLA-A2-restricted CD8 + T cel...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2005, Vol.114 (1), p.70-78
Main Authors: Ayyoub, Maha, Merlo, Andrea, Hesdorffer, Charles S., Speiser, Daniel, Rimoldi, Donata, Cerottini, Jean-Charles, Ritter, Gerd, Chen, Yao-Tseng, Old, Lloyd J., Stevanovic, Stefan, Valmori, Danila
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Biological and medical sciences
Cancer
CD4 + T cells
CD4-Positive T-Lymphocytes - immunology
Cells, Cultured
Epitope Mapping
Epitopes, T-Lymphocyte - chemistry
Epitopes, T-Lymphocyte - genetics
Fundamental and applied biological sciences. Psychology
Fundamental immunology
HLA-DR Antigens - immunology
HLA-DR Serological Subtypes
HLA-DR3 Antigen - immunology
HLA-DRB1 Chains
Humans
Immunopathology
Immunotherapy
Medical sciences
Melanoma - immunology
Molecular Sequence Data
Neoplasm Proteins - immunology
Peptide Fragments - immunology
Repressor Proteins - immunology
SSX-2
T-Lymphocytes, Helper-Inducer - immunology
Tumor antigen
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Summary:Because of their specific expression in tumors of different histological types, the products of the SSX genes are important candidate targets for development of cancer vaccines. We have previously identified two immunodominant SSX-2-derived T cell epitopes recognized by HLA-A2-restricted CD8 + T cells (SSX-2 41–49) and HLA-DR11-restricted CD4 + T cells (SSX-2 45–59), respectively. In this study, we report the identification of an HLA-DR3-restricted epitope mapping to the 37–51 region of SSX-2, overlapping both previously identified epitopes. As about one fifth of individuals from several major ethnic groups express HLA-DR3, the identification of this epitope significantly increases the percent of patients that are expected to mount specific CD4 + T cell responses following vaccination with peptides in this region of SSX-2. Retrieval of multiple overlapping epitopes in a defined region of SSX-2 protein suggests the presence of a “hot spot” for T cell recognition that may prove sufficient for the induction of immune responses.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2004.08.014