Birth Weight, Early Weight Gain, and Subsequent Risk of Type 1 Diabetes: Systematic Review and Meta-Analysis

Previous studies suggest that birth weight and weight gain during the first year of life are related to later risk of type 1 diabetes. The authors performed a systematic review and meta-analysis on these associations. Twelve studies involving 2,398,150 persons of whom 7,491 had type 1 diabetes provi...

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Bibliographic Details
Published in:American journal of epidemiology 2009-06, Vol.169 (12), p.1428-1436
Main Authors: Harder, Thomas, Roepke, Katharina, Diller, Natasha, Stechling, Yvonne, Dudenhausen, Joachim W., Plagemann, Andreas
Format: Article
Language:English
Subjects:
Age Factors
Analysis. Health state
Biological and medical sciences
Birth Weight
Confidence Intervals
Diabetes
diabetes mellitus
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
General aspects
Humans
Infant
Infant, Newborn
Male
Medical sciences
Meta-analysis
Miscellaneous
Obesity - epidemiology
Obesity - etiology
Obesity - physiopathology
Odds Ratio
Public health. Hygiene
Public health. Hygiene-occupational medicine
Regression Analysis
Risk Factors
type 1
United States - epidemiology
Weight
Weight Gain
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Summary:Previous studies suggest that birth weight and weight gain during the first year of life are related to later risk of type 1 diabetes. The authors performed a systematic review and meta-analysis on these associations. Twelve studies involving 2,398,150 persons of whom 7,491 had type 1 diabetes provided odds ratios and 95% confidence intervals of type 1 diabetes associated with birth weight. Four studies provided data on weight and/or weight gain during the first year of life. High birth weight (>4,000 g) was associated with increased risk of type 1 diabetes (odds ratio = 1.17, 95% confidence interval (CI): 1.09, 1.26). According to sensitivity analysis, this result was not influenced by particular study characteristics. The pooled confounder-adjusted estimate was 1.43 (95% CI: 1.11, 1.85). No heterogeneity was found (I2 = 0%) and no publication bias. Low birth weight (
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwp065