Blood vessel formation after soft-tissue implantation of hyaluronan-based hydrogel supplemented with copper ions

The possibility of ameliorating bone healing of implanted bone allografts is a field of great interest. Early vascular invasion is a key factor in bone allograft incorporation. It is well known that copper ions (Cu 2+) show a proangiogenic action favouring the development of new vessels. In this wor...

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Bibliographic Details
Published in:Biomaterials 2005-06, Vol.26 (16), p.3001-3008
Main Authors: Giavaresi, G., Torricelli, P., Fornasari, P.M., Giardino, R., Barbucci, R., Leone, G.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Bone and Bones - metabolism
Bone Regeneration
Bone Substitutes - pharmacology
Bone Transplantation
Copper - chemistry
Copper ions
Female
Freeze-dried bone allograft
Hyaluronan
Hyaluronic Acid - chemistry
Hydrogel
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Ions
Light
Male
Microscopy, Electron, Scanning
Neovascularization, Physiologic
Osseointegration
Rats
Rats, Sprague-Dawley
Rats, Wistar
Soft-tissue implants
Spectroscopy, Fourier Transform Infrared
Vessel formation
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Summary:The possibility of ameliorating bone healing of implanted bone allografts is a field of great interest. Early vascular invasion is a key factor in bone allograft incorporation. It is well known that copper ions (Cu 2+) show a proangiogenic action favouring the development of new vessels. In this work a hyaluronan based 50% hydrogel (Hyal-50%) was enriched with (Cu 2+) and its proangiogenic activity was evaluated. Fifteen Sprague Dawley female rats were submitted to the subcutaneous implantation of Hyal-50%, freeze-dried bone allografts, Hyal-50%-Cu 2+, freeze-dried bone allografts plus Hyal-50% and freeze-dried bone allografts plus Hyal-50%-Cu 2+. One month later, histomorphometric analysis evidenced the presence of a fibrous-reactive capsule around all specimens showing significant differences among groups ( p
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2004.08.027