The peripheral blood Valpha24+ NKT cell numbers decrease in patients with haematopoietic malignancy

Valpha24TCR+ CD161+ NKT (Valpha24+ NKT) cells are activated by alpha-galactosylceramide and can exert anti-tumor activity against a variety of tumor cells. In this study, we assessed the Valpha24+ NKT cell numbers in peripheral blood (PB) from 30 healthy donors and 70 patients with haematopoietic ma...

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Bibliographic Details
Published in:Leukemia research 2005-02, Vol.29 (2), p.147-152
Main Authors: Yoneda, Ken-ichirou, Morii, Takeshi, Nieda, Mie, Tsukaguchi, Nobuhiko, Amano, Itsuto, Tanaka, Haruyuki, Yagi, Hideo, Narita, Nobuhiro, Kimura, Hiroshi
Format: Article
Language:English
Subjects:
CD4 Antigens - biosynthesis
CD8 Antigens - biosynthesis
Flow Cytometry
Hematologic Neoplasms - blood
Humans
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Lymphocyte Count
Lymphocytes - cytology
Lymphocytes - immunology
Receptors, Antigen, T-Cell, alpha-beta - biosynthesis
Survival Analysis
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Summary:Valpha24TCR+ CD161+ NKT (Valpha24+ NKT) cells are activated by alpha-galactosylceramide and can exert anti-tumor activity against a variety of tumor cells. In this study, we assessed the Valpha24+ NKT cell numbers in peripheral blood (PB) from 30 healthy donors and 70 patients with haematopoietic malignancy including chronic myelogenous leukemia (CML), malignant lymphoma (ML), acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). Here, we demonstrated that PB Valpha24+ NKT cell numbers were significantly decreased in all the patients with haematopoietic malignancy in comparison with that in healthy donors (P < 0.005). In particular CD4- CD8- Valpha24+ NKT cell numbers were more significantly decreased in the patients with haematopoietic malignancy (P < 0.0001).
ISSN:0145-2126