Clinical value of serum squamous cell carcinoma antigen in the management of sinonasal inverted papilloma

Background. Although sinonasal inverted papilloma (IP) is a rare benign tumor, it has a tendency to recur and is sometimes associated with squamous cell carcinoma (SCC). Therefore, postoperative long‐term follow‐up of these patients is recommended. We previously reported that serum SCC antigen might...

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Bibliographic Details
Published in:Head & neck 2005-01, Vol.27 (1), p.44-48
Main Authors: Yasumatsu, Ryuji, Nakashima, Torahiko, Masuda, Muneyuki, Kuratomi, Yuichiro, Shiratsuchi, Hideki, Hirakawa, Naoya, Tomita, Kichinobu, Yamamoto, Tomoya, Komune, Shizuo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - blood
Biological and medical sciences
Biomarkers, Tumor - blood
Carcinoma, Squamous Cell - blood
Child
Female
Humans
inverted papilloma
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Otorhinolaryngology. Stomatology
Papilloma, Inverted - blood
Papilloma, Inverted - surgery
Paranasal Sinus Neoplasms - blood
Paranasal Sinus Neoplasms - surgery
Reference Values
sinonasal tract
squamous cell carcinoma antigen
tumor marker
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Summary:Background. Although sinonasal inverted papilloma (IP) is a rare benign tumor, it has a tendency to recur and is sometimes associated with squamous cell carcinoma (SCC). Therefore, postoperative long‐term follow‐up of these patients is recommended. We previously reported that serum SCC antigen might be a useful tumor marker for sinonasal IP. In this study, we investigated whether serum SCC antigen level has a correlation with disease status and is useful in the early detection of recurrent disease. Methods. Blood samples for the analysis of serum SCC antigen were taken from 28 IP patients before and after surgical treatment. Results. Twenty‐five (89%) of 28 cases showed evaluated serum SCC antigen levels above the upper limit. This marker level decreased in all cases after surgical resection. Four of these patients had a recurrence. None of the patients with recurrent tumor showed symptoms at the time of detection of their recurrent tumor, and recurrence was discovered from elevated levels of SCC antigen. Conclusions. Serum SCC antigen level has a correlation with disease status of IP and has a potential to serve as a useful tool for monitoring the course of disease. SCC antigen is a reliable tumor marker in the management of sinonasal IPs. © 2004 Wiley Periodicals, Inc. Head Neck 27: 44–48, 2005
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.20115