A New Target for POLO in Meiotic Centromere Cohesion

The POLO kinase is a key regulator of the release of sister chromatid cohesion at the onset of mitotic anaphase, as well as of other features of the mitotic and meiotic processes. In this issue of Developmental Cell, Clarke et al. show that POLO also regulates the function of the MEI-S332 protein, w...

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Bibliographic Details
Published in:Developmental Cell 2005, Vol.8 (1), p.5-7
Main Authors: Lake, Cathleen M., Hawley, R.Scott
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Centromere - metabolism
Drosophila melanogaster
Drosophila Proteins - physiology
Fundamental and applied biological sciences. Psychology
Meiosis - physiology
Molecular and cellular biology
Protein-Serine-Threonine Kinases - physiology
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Summary:The POLO kinase is a key regulator of the release of sister chromatid cohesion at the onset of mitotic anaphase, as well as of other features of the mitotic and meiotic processes. In this issue of Developmental Cell, Clarke et al. show that POLO also regulates the function of the MEI-S332 protein, which plays a critical role in the maintenance of sister chromatid cohesion at the centromere during meiosis.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2004.12.012