‘Ins and outs’ of seven-transmembrane receptor signalling to ERK

Extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are important members of the mitogen-activated protein kinase (MAPK) family and have emerged as key effector targets of activation by seven-transmembrane-spanning (G-protein-coupled) receptors (7TMRs). Regulation of ERK by 7TMRs is highly compl...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2005, Vol.16 (1), p.26-33
Main Authors: Werry, Tim D., Sexton, Patrick M., Christopoulos, Arthur
Format: Article
Language:English
Subjects:
Animals
Arrestins - physiology
Biological and medical sciences
Cell physiology
Fundamental and applied biological sciences. Psychology
GTP-Binding Proteins - physiology
Humans
Mitogen-Activated Protein Kinases - physiology
Molecular and cellular biology
Signal transduction
Signal Transduction - physiology
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Summary:Extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are important members of the mitogen-activated protein kinase (MAPK) family and have emerged as key effector targets of activation by seven-transmembrane-spanning (G-protein-coupled) receptors (7TMRs). Regulation of ERK by 7TMRs is highly complex and dependent on cell type. Numerous studies have linked specific G protein pathways to ERK activation, but recent evidence suggests that some 7TMR-linked ERK signalling pathways might not be exclusively mediated by G proteins. In addition, the emergence of an ‘inside-out’ model for receptor tyrosine kinase (RTK) ‘transactivation’ by 7TMRs has enhanced our understanding of the ERK signalling system and further underscores the complexity of mitogenic regulation by 7TMRs.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2004.11.008