Andes virus stimulates interferon-inducible MxA protein expression in endothelial cells

MxA is a cellular protein activated in cells treated with type I interferons. MxA protein is a member of the dynamin superfamily of large guanosine triphosphatases. A unique property of Mx1 GTPases is their antiviral activity against a wide range of RNA viruses. Replication of several hantavirus str...

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Bibliographic Details
Published in:Journal of medical virology 2005-02, Vol.75 (2), p.267-275
Main Authors: Khaiboullina, Svetlana F., Rizvanov, Albert A., Deyde, Varough M., St. Jeor, Stephen C.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Line
Cercopithecus aethiops
endothelial cell
Endothelial Cells - immunology
Endothelial Cells - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - immunology
GTP-Binding Proteins - biosynthesis
GTP-Binding Proteins - immunology
hantavirus
Hantavirus - immunology
Hantavirus Infections - immunology
Hantavirus Infections - metabolism
Human viral diseases
Humans
Infectious diseases
interferon
Medical sciences
Microbiology
Miscellaneous
MxA
Myxovirus Resistance Proteins
Up-Regulation
Vero Cells
Viral diseases
Virology
Virus Replication - immunology
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Summary:MxA is a cellular protein activated in cells treated with type I interferons. MxA protein is a member of the dynamin superfamily of large guanosine triphosphatases. A unique property of Mx1 GTPases is their antiviral activity against a wide range of RNA viruses. Replication of several hantavirus strains is inhibited in cells constitutively expressing MxA protein. We have found that Andes virus (ANDV) infection up regulates transcription of MxA RNA and expression of MxA protein in human endothelial cells in vitro. Activation of MxA gene expression requires virus replication. Up‐regulation of MxA gene expression in hantavirus infected cells varies depending on the cell type. The degree of activation of MxA gene expression is inversely correlated with the efficiency of hantavirus replication. Additionally, MxA protein is co‐localized with hantavirus nucleocapsid protein in infected cell. Our data suggest that MxA by interacting with the virus nucleocapsid protein inhibits production of new infectious virus particles. J. Med. Virol. 75:267–275, 2005. © 2004 Wiley‐Liss, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.20266